Design, synthesis, and biological evaluation of steroidal analogs as estrogenic/anti-estrogenic agents
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DOI: 10.1016/j.steroids.2016.11.005
Abstract: HIGHLIGHTSSeries of estrone analogs were synthesized.Cell proliferation, cytotoxicity, and estrogenic/anti‐estrogenic activities were evaluated.LA‐7 alcohol derivative exhibited selective anti‐estrogenic activity towards ER‐&agr; at 5.49 &mgr;M. ABSTRACT Series of estrone based analogs were synthetically investigated at positions… read more here.
Keywords: design synthesis; anti estrogenic; affinity towards; towards agr ... See more keywords