TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver.
Sign Up to like & getrecommendations! Published in 2021 at "Cell metabolism"
DOI: 10.1016/j.cmet.2021.11.013
Abstract: Increased hepatic glucose production (HGP) contributes to hyperglycemia in type 2 diabetes. Hormonal regulation of this process is primarily, but not exclusively, mediated by the AKT-FoxO1 pathway. Here, we show that cAMP and dexamethasone regulate… read more here.
Keywords: glucose production; insulin; tox4; insulin receptor ... See more keywords
Tox4 modulates cell fate reprogramming
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.232223
Abstract: ABSTRACT Reprogramming to induced pluripotency induces the switch of somatic cell identity to induced pluripotent stem cells (iPSCs). However, the mediators and mechanisms of reprogramming remain largely unclear. To elucidate the mediators and mechanisms of… read more here.
Keywords: tox4; modulates cell; early reprogramming; cell fate ... See more keywords