Enhancing safety and efficacy by altering the toxic aggregated state of Amphotericin B in lipidic nanoformulations.
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DOI: 10.1021/acs.molpharmaceut.0c00313
Abstract: The toxicity of Amphotericin B (AmB) is contributed by the small, water-soluble aggregates of the drug. Hence, AmB lipid polymer hybrid nanoparticles (LIPOMER), comprising of stearate lipids with a hydrophilic polymer Gantrez (GZ), and solid… read more here.
Keywords: safety efficacy; efficacy; toxic aggregated; altering toxic ... See more keywords