CYP3A4/5 mediates the metabolic detoxification of humantenmine, a highly toxic alkaloid from Gelsemium elegans Benth.
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DOI: 10.1002/jat.3813
Abstract: Gelsemium elegans Benth., a well‐known toxic herbal plant, is widely used to treat rheumatic arthritis, inflammation and other diseases. Gelsemium contains humantenmine (HMT), which is an important bioactive and toxic alkaloid. Cytochrome P450 enzymes (CYPs)… read more here.
Keywords: detoxification; gelsemium elegans; hmt; toxic alkaloid ... See more keywords