Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma: The ORATOR2 Phase 2 Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.0615
Abstract: Importance The optimal approach for treatment deescalation in human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OPSCCs) is unknown. Objective To assess a primary radiotherapy (RT) approach vs a primary transoral surgical (TOS) approach in treatment… read more here.
Keywords: trial; randomized clinical; treatment deescalation; toxic effects ... See more keywords
Effect of Supine vs Prone Breast Radiotherapy on Acute Toxic Effects of the Skin Among Women With Large Breast Size: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.1479
Abstract: Importance Women with large breast size treated with adjuvant breast radiotherapy (RT) have a high rate of acute toxic effects of the skin. Breast RT in the prone position is one strategy that may decrease… read more here.
Keywords: breast; trial; prone; toxic effects ... See more keywords
Treatment With Stereotactic Ablative Radiotherapy for Up to 5 Oligometastases in Patients With Cancer: Primary Toxic Effect Results of the Nonrandomized Phase 2 SABR-5 Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.4394
Abstract: Importance After the publication of the landmark SABR-COMET trial, concerns arose regarding high-grade toxic effects of treatment with stereotactic ablative body radiotherapy (SABR) for oligometastases. Objective To document toxic effects of treatment with SABR in… read more here.
Keywords: sabr; trial; phase; toxic effects ... See more keywords
The toxic effects of yeast Ppz1 phosphatase are counteracted by subcellular relocalization mediated by its regulatory subunit Hal3
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14330
Abstract: Overexpression of Saccharomyces cerevisiae protein phosphatase Ppz1 strongly impairs cell growth. Ppz1 is negatively regulated by its subunit Hal3, and Hal3 overexpression fully counteracts the toxic effects derived from high levels of the phosphatase. We show… read more here.
Keywords: phosphatase; hal3; subunit hal3; ppz1 ... See more keywords
Toxic effects of dimethyl sulfoxide on red blood cells, platelets, and vascular endothelial cells in vitro
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12193
Abstract: Dimethyl sulfoxide (DMSO) is widely used in biological studies as a cryoprotective agent for cells and tissues, and also for cryopreserved platelets (PLTs). However, few data on the toxic effects of DMSO following intravenous infusion… read more here.
Keywords: red blood; vascular endothelial; toxic effects; dimethyl sulfoxide ... See more keywords
Herbicide Roundup shows toxic effects in nontarget organism Drosophila.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21893
Abstract: Glyphosate-based herbicide Roundup, as the most employed herbicide used for multiple purposes in agriculture, adversely affects nontarget organisms. We tested the effects of Roundup applied at larval and adult stages. Roundup caused developmental delay and… read more here.
Keywords: roundup; toxic effects; roundup shows; herbicide roundup ... See more keywords
Enantioselective toxic effects and digestion of furalaxyl enantiomers in Scenedesmus obliquus.
Sign Up to like & getrecommendations! Published in 2018 at "Chirality"
DOI: 10.1002/chir.23020
Abstract: Research on the enantioselective environmental behavior of chiral pesticides has been a hot spot of environmental chemistry recently. In this study, the acute toxicity and digestion of furalaxyl enantiomers were determined on the aquatic algae… read more here.
Keywords: digestion furalaxyl; toxic effects; furalaxyl; furalaxyl enantiomers ... See more keywords
Toxic Effects of PCB Congeners and Aroclors on Embryonic Growth and Development.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.4908
Abstract: Polychlorinated biphenyls (PCBs) cause significant health and reproductive problems in many vertebrates. Exposure during embryogenesis likely leads to defects in organ development, compromising survival and growth through adulthood. This study identifies the impact of PCBs… read more here.
Keywords: survival growth; toxic effects; pcb congeners; adulthood ... See more keywords
Toxic effects of nanomaterials for health applications: How automation can support a systematic review of the literature?
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4204
Abstract: Systematic reviews of the scientific literature can be an important source of information supporting the daily work of the regulators in their decision making, particularly in areas of innovative technologies where the regulatory experience is… read more here.
Keywords: toxic effects; effects nanomaterials; systematic review; literature ... See more keywords
Toxicological effects of Tris (1,3‐dichloro‐2‐propyl) phosphate exposure in adult male rats differ depending on the history of exposure in the neonatal period
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4316
Abstract: There is increasing concern about multiple high concentration exposure to toxins in disaster and emergency situations. However, conventional toxicology testing methods may not adequately address these situations. Thus, we assessed whether the toxic effects of… read more here.
Keywords: toxicology; history; day; differ depending ... See more keywords
Toxic effects of triptolide on adrenal steroidogenesis in H295R cells and female rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22394
Abstract: Triptolide (TP), a major active ingredient of Tripterygium wilfordii, exerts potent immunosuppressive effects in the treatment of rheumatoid arthritis but is not widely used in clinical practice due to its multiorgan toxicity, particularly hepatotoxicity, nephrotoxicity,… read more here.
Keywords: triptolide adrenal; adrenal steroidogenesis; h295r; h295r cells ... See more keywords