Caspase-cleaved tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Psychiatry"
DOI: 10.1038/s41380-022-01538-2
Abstract: The microtubule-associated protein tau plays a central role in tauopathies such as Alzheimer’s disease (AD). The exact molecular mechanisms underlying tau toxicity are unclear, but aging is irrefutably the biggest risk factor. This raises the… read more here.
Keywords: transport; axonal transport; interaction; microtubule interaction ... See more keywords
Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid
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DOI: 10.1038/s41467-018-03651-9
Abstract: Peptide mediated gain-of-toxic function is central to pathology in Alzheimer’s, Parkinson’s and diabetes. In each system, self-assembly into oligomers is observed and can also result in poration of artificial membranes. Structural requirements for poration and… read more here.
Keywords: gain; iapp; poration; toxic gain ... See more keywords
Towards Personalized Allele-Specific Antisense Oligonucleotide Therapies for Toxic Gain-of-Function Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14081708
Abstract: Antisense oligonucleotides (ASOs) are single-stranded nucleic acid strings that can be used to selectively modify protein synthesis by binding complementary (pre-)mRNA sequences. By specific arrangements of DNA and RNA into a chain of nucleic acids… read more here.
Keywords: toxic gain; personalized allele; gain function; allele specific ... See more keywords