Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases.
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DOI: 10.1021/acs.accounts.3c00045
Abstract: ConspectusThe aberrant misfolding and aggregation of peptides and proteins into amyloid aggregates occurs in over 50 largely incurable protein misfolding diseases. These pathologies include Alzheimer's and Parkinson's diseases, which are global medical emergencies owing to… read more here.
Keywords: misfolding diseases; misfolded protein; protein misfolding; toxic nontoxic ... See more keywords