Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid.
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DOI: 10.1021/acschemneuro.2c00498
Abstract: Alzheimer's disease is imposing a growing social and economic burden worldwide, and effective therapies are urgently required. One possible approach to modulation of the disease outcome is to use small molecules to limit the conversion… read more here.
Keywords: conjugates rapidly; macrocycle conjugates; perphenazine macrocycle; toxic oligomers ... See more keywords
The role of α-sheet structure in amyloidogenesis: characterization and implications
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DOI: 10.1098/rsob.220261
Abstract: Amyloid diseases are linked to protein misfolding whereby the amyloidogenic protein undergoes a conformational change, aggregates and eventually forms amyloid fibrils. While the amyloid fibrils and plaques are hallmarks of these diseases, they typically form… read more here.
Keywords: role sheet; structure; toxic oligomers; sheet structure ... See more keywords
Development of Alkaline Phosphatase-Fused Mouse Prion Protein and Its Application in Toxic Aβ Oligomer Detection
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DOI: 10.3390/ijms232314588
Abstract: Amyloid β (Aβ) oligomers play a key role in the progression of Alzheimer’s disease (AD). Multiple forms of Aβ assemblies have been identified by in vitro and in vivo analyses; however, it is uncertain which… read more here.
Keywords: alp; prion protein; toxic oligomers; prp alp ... See more keywords