Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55419-w
Abstract: The pathological aggregation and accumulation of tau, a microtubule-associated protein, is a common feature amongst more than 18 different neurodegenerative diseases that are collectively known as tauopathies. Recently, it has been demonstrated that the soluble… read more here.
Keywords: aggregation; tau; toxic tau; curcumin derivatives ... See more keywords
Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc05072d
Abstract: Well-defined heparin like oligosaccharides up to decasaccharides were synthesized. It was discovered for the first time that heparin oligosaccharides, as short as tetrasaccharides, can bind with the most toxic tau species, i.e., tau oligomers with… read more here.
Keywords: heparin like; like oligosaccharides; tau oligomers; toxic tau ... See more keywords
Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.702788
Abstract: The human tau protein is implicated in a wide range of neurodegenerative “tauopathy” diseases, consisting of Alzheimer’s disease (AD) and frontotemporal lobar degeneration which includes progressive supranuclear palsy, corticobasal degeneration, Pick’s disease, and FTLD-tau (frontotemporal… read more here.
Keywords: tau; toxic tau; human tau; tau fragments ... See more keywords
Toxic tau: structural origins of tau aggregation in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2020 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.274329
Abstract: Alzheimer’s disease is characterized by the extracellular accumulation of the amyloid β in the form of amyloid plaques and the intracellular deposition of the microtubule-associated protein tau in the form of neurofibrillary tangles. Most of… read more here.
Keywords: alzheimer disease; toxic tau; tau protein; disease ... See more keywords