Evaluation of a Comprehensive Skin Toxicity Program for Patients Treated With Epidermal Growth Factor Receptor Inhibitors at a Cancer Treatment Center.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2020.1795
Abstract: Importance Up to 90% of patients treated with an epidermal growth factor receptor inhibitor (EGFRi) experience cutaneous toxic effects that are negatively associated with quality of life and lead to treatment interruptions. The Skin Toxicity… read more here.
Keywords: skin toxicity; treatment; program; toxicity ... See more keywords
The degree of unsaturation of fatty acids in phosphatidylserine alters the rate of insulin aggregation and the structure and toxicity of amyloid aggregates
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14369
Abstract: Phosphatidylserine (PS) in the plasma membrane plays an important role in cell signaling and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies that are associated with aggregation of misfolded proteins. In this… read more here.
Keywords: aggregation; toxicity; structure toxicity; unsaturation fatty ... See more keywords
Regucalcin confers resistance to amyloid‐β toxicity in neuronally differentiated PC12 cells
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12374
Abstract: Amyloid‐β (Aβ), a primary component of amyloid plaques, has been widely associated with the pathogenesis of Alzheimer's disease. The Ca2+‐binding protein regucalcin (RGN) plays multiple roles in maintaining cell functions by regulating intracellular calcium homeostasis,… read more here.
Keywords: pc12 cells; toxicity; neuronally differentiated; regucalcin confers ... See more keywords
An Optimally Fabricated Platform Guides Cancer‐Specific Activation of Chemotherapeutic Drugs and Toxicity‐Free Cancer Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200765
Abstract: Cancer chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine, which are mostly small synthetic molecules, are still clinically useful for cancer treatment. However, despite considerable therapeutic efficacy, severe toxicity‐associated problems, which are mainly caused… read more here.
Keywords: chemotherapeutic drugs; platform; toxicity; cancer treatment ... See more keywords
Nanocomplexes of Biodegradable Anticancer Macromolecules: Prolonged Plasma Half-life, Reduced Toxicity, and Increased Tumor Targeting.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202201560
Abstract: Anticancer drug resistance is a large contributing factor to the global mortality rate of cancer patients. Anticancer macromolecules such as polymers were recently reported to overcome this issue. Anticancer macromolecules have unselective toxicity because they… read more here.
Keywords: toxicity; half; anticancer macromolecules; anticancer ... See more keywords
Toxicity and Biocompatibility of Liquid Metals
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201924
Abstract: Recently, room‐temperature liquid metals have attracted increasing attention from researchers owing to their excellent material properties. Systematic interpretation of the potential toxicity issues involved is essential for a wide range of applications, especially in the… read more here.
Keywords: liquid metal; toxicology; toxicity; liquid metals ... See more keywords
Prolonged hematologic toxicity following treatment with chimeric antigen receptor T cells in patients with hematologic malignancies
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26113
Abstract: Chimeric antigen receptor T‐cell therapy (CAR T) is a novel intervention for relapsed/refractory diffuse large B‐cell lymphoma (R/R DLBCL) and other hematologic malignancies. However, it is associated with prolonged hematologic toxicity (PHT) that is unpredictable… read more here.
Keywords: hematologic toxicity; cell therapy; prolonged hematologic; toxicity ... See more keywords
Toxicity of procymidone to Bombyx mori based on physiological and transcriptomic analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21906
Abstract: Procymidone is widely used in vegetables and fruits because of its broad-spectrum and high efficiency. However, it is unclear whether procymidone can affect silkworm (Bombyx mori) growth and cocoon production. This study investigated the effects… read more here.
Keywords: growth cocoon; transcriptomic analysis; toxicity; procymidone ... See more keywords
Acute toxicity and antitumor potential of 1,3,4‐trisubstituted‐1,2,3‐triazole dhmtAc‐loaded liposomes on a triple‐negative breast cancer model
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200004
Abstract: For the first time, compounds developed from the 1,2,3‐triazole scaffold were evaluated as novel drugs to treat triple‐negative breast cancer (TNBC). Four organic salts were idealized as nonclassical bioisosteres of miltefosine, which is used in… read more here.
Keywords: triple negative; toxicity; triazole; dhmtac ... See more keywords
Emergence of nanomaterial as potential immobilization support for whole cell biocatalyst and cell toxicity effects.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2034
Abstract: The traditional approach of fermentation by a free cell system has limitations of low productivity and product separation that need to be addressed for production enhancement and for cost effectiveness. One of the potential methods… read more here.
Keywords: immobilization; emergence nanomaterial; toxicity; cell ... See more keywords
Synthesized nanoliposome‐encapsulated kaempferol attenuates liver health parameters and gene expression in mice challenged by cadmium‐induced toxicity
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2368
Abstract: In the present research, we encapsulated a flavonoid called kaempferol into nanoliposomal structures and the health‐promoting effects of synthesized nanoliposome‐loaded kaempferol (NLK) were evaluated in mice challenged by cadmium‐induced . The NLK characteristics, such as… read more here.
Keywords: kaempferol; cadmium induced; challenged cadmium; cadmium ... See more keywords