Evaluation of a Comprehensive Skin Toxicity Program for Patients Treated With Epidermal Growth Factor Receptor Inhibitors at a Cancer Treatment Center.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2020.1795
Abstract: Importance Up to 90% of patients treated with an epidermal growth factor receptor inhibitor (EGFRi) experience cutaneous toxic effects that are negatively associated with quality of life and lead to treatment interruptions. The Skin Toxicity… read more here.
Keywords: skin toxicity; treatment; program; toxicity ... See more keywords
The degree of unsaturation of fatty acids in phosphatidylserine alters the rate of insulin aggregation and the structure and toxicity of amyloid aggregates
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14369
Abstract: Phosphatidylserine (PS) in the plasma membrane plays an important role in cell signaling and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies that are associated with aggregation of misfolded proteins. In this… read more here.
Keywords: aggregation; toxicity; structure toxicity; unsaturation fatty ... See more keywords
Regucalcin confers resistance to amyloid‐β toxicity in neuronally differentiated PC12 cells
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12374
Abstract: Amyloid‐β (Aβ), a primary component of amyloid plaques, has been widely associated with the pathogenesis of Alzheimer's disease. The Ca2+‐binding protein regucalcin (RGN) plays multiple roles in maintaining cell functions by regulating intracellular calcium homeostasis,… read more here.
Keywords: pc12 cells; toxicity; neuronally differentiated; regucalcin confers ... See more keywords
An Optimally Fabricated Platform Guides Cancer‐Specific Activation of Chemotherapeutic Drugs and Toxicity‐Free Cancer Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200765
Abstract: Cancer chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine, which are mostly small synthetic molecules, are still clinically useful for cancer treatment. However, despite considerable therapeutic efficacy, severe toxicity‐associated problems, which are mainly caused… read more here.
Keywords: chemotherapeutic drugs; platform; toxicity; cancer treatment ... See more keywords
Nanocomplexes of Biodegradable Anticancer Macromolecules: Prolonged Plasma Half-life, Reduced Toxicity, and Increased Tumor Targeting.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202201560
Abstract: Anticancer drug resistance is a large contributing factor to the global mortality rate of cancer patients. Anticancer macromolecules such as polymers were recently reported to overcome this issue. Anticancer macromolecules have unselective toxicity because they… read more here.
Keywords: toxicity; half; anticancer macromolecules; anticancer ... See more keywords
Toxicity and Biocompatibility of Liquid Metals
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201924
Abstract: Recently, room‐temperature liquid metals have attracted increasing attention from researchers owing to their excellent material properties. Systematic interpretation of the potential toxicity issues involved is essential for a wide range of applications, especially in the… read more here.
Keywords: liquid metal; toxicology; toxicity; liquid metals ... See more keywords
A Sustained H2/Fluorouracil‐Releasing Suppository for High‐efficacy and Low‐Toxicity Hydrogenochemotherapy of Colon Cancer
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202404054
Abstract: To attenuate the intestinal toxicity of chemotherapeutic drugs from rectal suppositories and enhance their chemotherapeutic outcome is greatly significant, but maintains a challenge. In this work, a new strategy of local synergistic hydrogenochemotherapy is proposed… read more here.
Keywords: cancer; suppository high; colon; toxicity ... See more keywords
A High‐Throughput Approach to Identifying Environment‐Friendly Artificial Antisolvents for Efficient Perovskite Solar Cells
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Materials"
DOI: 10.1002/adma.202504602
Abstract: Rapid crystallization facilitated by antisolvents is widely employed for producing high‐quality perovskite films, but constrained by the limited variety and high toxicity of conventional solvents, underscoring the need for sustainable and low‐toxicity solvent systems for… read more here.
Keywords: perovskite films; high throughput; friendly artificial; toxicity ... See more keywords
Nanotherapeutics for Alleviating Anesthesia‐Associated Complications
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202308241
Abstract: Current management of anesthesia‐associated complications falls short in terms of both efficacy and safety. Nanomaterials with versatile properties and unique nano‐bio interactions hold substantial promise as therapeutics for addressing these complications. This review conducts a… read more here.
Keywords: anesthesia associated; alleviating anesthesia; associated complications; toxicity ... See more keywords
Gastrointestinal Incomplete Degradation Exacerbates Neurotoxic Effects of PLA Microplastics via Oligomer Nanoplastics Formation
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202401009
Abstract: Biodegradable plastics, hailed for their environmental friendliness, may pose unforeseen risks as they undergo gastrointestinal degradation, forming oligomer nanoplastics. Despite this, the influence of gastrointestinal degradation on the potential human toxicity of biodegradable plastics remains… read more here.
Keywords: pla polymer; toxicity; oligomer nanoplastics; degradation ... See more keywords
Machine Learning‐Enabled Drug‐Induced Toxicity Prediction
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202413405
Abstract: Unexpected toxicity has become a significant obstacle to drug candidate development, accounting for 30% of drug discovery failures. Traditional toxicity assessment through animal testing is costly and time‐consuming. Big data and artificial intelligence (AI), especially… read more here.
Keywords: induced toxicity; toxicity prediction; drug; toxicity ... See more keywords