Sign Up to like & get
recommendations!
2
Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9337
Abstract: In the era of immunotherapies and targeted therapies, the focus of early phase clinical trials has shifted from finding the maximum tolerated dose to identifying the optimal biological dose (OBD), which maximizes the toxicity‐efficacy trade‐off.…
read more here.
Keywords:
efficacy;
design;
tite boin12;
toxicity efficacy ... See more keywords
Sign Up to like & get
recommendations!
1
Published in 2020 at "Clinical genitourinary cancer"
DOI: 10.1016/j.clgc.2020.10.003
Abstract: BACKGROUND Nivolumab, a programmed death 1 inhibitor, has been approved as second-line treatment for advanced renal cell carcinoma (RCC) in Europe since 2016. We investigated the toxicity and efficacy of nivolumab as well as potential…
read more here.
Keywords:
treatment;
efficacy;
toxicity;
toxicity efficacy ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2020 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2020.1815033
Abstract: ABSTRACT The rise of targeted therapy and immunotherapy has challenged the conventional more-is-better phase I trial design paradigm that focuses on finding the MTD. In this article, we propose a novel model-assisted phase I/II design,…
read more here.
Keywords:
phase;
efficacy;
toxicity efficacy;
checkerboard design ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e14060
Abstract: e14060Background: SMK/SM-88 is a combination of novel tyrosine isomer (TI) and 3 low dose repurposed agents that are generally recognized as safe for typical use. Its mechanism of action is based o...
read more here.
Keywords:
efficacy patient;
smk;
toxicity efficacy;
smk sm88 ... See more keywords
Sign Up to like & get
recommendations!
1
Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154704
Abstract: Chaga mushroom (Inonotus obliquus) comprises polyphenolic compounds, triterpenoids, polysaccharides, and sterols. Among the triterpenoid components, inotodiol has been broadly examined because of its various biological activities. The purpose of this study is to examine inotodiol…
read more here.
Keywords:
evaluation toxicity;
efficacy inotodiol;
toxicity;
toxicity efficacy ... See more keywords