Nuclear localized C9orf72-associated arginine-containing dipeptides exhibit age-dependent toxicity in C. elegans
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DOI: 10.1093/hmg/ddx372
Abstract: Abstract A hexanucleotide repeat expansion mutation in the C9orf72 gene represents a prevalent genetic cause of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Non-canonical translation of this repeat gives rise to… read more here.
Keywords: toxicity elegans; age; containing dipeptides; arginine containing ... See more keywords