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Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9591
Abstract: The growing interest in new classes of anti‐cancer agents, such as molecularly‐targeted therapies and immunotherapies with modes of action different from those of cytotoxic chemotherapies, has changed the dose‐finding paradigm. In this setting, the observation…
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Keywords:
toxicity endpoints;
progression;
toxicity;
crm ... See more keywords
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Published in 2018 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2018.06.013
Abstract: ABSTRACT Benchmark dose (BMD) analysis is generally recognized superior to generate a point of departure (PoD) to conduct risk assessment on environmental toxicants, comparing with the traditionally employed no observed adverse effect level (NOAEL) or…
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Keywords:
thyroid toxicity;
analysis;
benchmark dose;
toxicity endpoints ... See more keywords