Exploratory studies with NX-13: oral toxicity and pharmacokinetics in rodents of an orally active, gut-restricted first-in-class therapeutic for IBD that targets NLRX1.
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DOI: 10.1080/01480545.2019.1679828
Abstract: Nucleotide-binding oligomerization domain, leucine rich repeat containing X1 (NLRX1) is an emerging therapeutic target for a spectrum of human diseases. NX-13 is a small molecule therapeutic designed to target and activate NLRX1 to induce immunometabolic… read more here.
Keywords: exploratory studies; toxicity pharmacokinetics; pharmacokinetics rodents; toxicity ... See more keywords
A Review of Pharmacology, Toxicity and Pharmacokinetics of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside
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DOI: 10.3389/fphar.2021.791214
Abstract: Polygonum multiflorum Thunb. (He-shou-wu in Chinese), a Chinese botanical drug with a long history, is widely used to treat a variety of chronic diseases in clinic, and has been given the reputation of “rejuvenating and… read more here.
Keywords: tsg; pharmacology; review; toxicity pharmacokinetics ... See more keywords
Toxicity, Pharmacokinetics, and Gut Microbiome of Oral Administration of Sesterterpene MHO7 Derived from a Marine Fungus
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DOI: 10.3390/md17120667
Abstract: Sesterterpene MHO7 derived from mangrove fungus is a novel estrogen receptor degrader for the treatment of breast cancer. To explore its safety and pharmacokinetics in vivo, Log P/D values, stability in simulated gastric/intestinal (SGF/SIF), toxicity,… read more here.
Keywords: mho7 derived; administration; toxicity pharmacokinetics; sesterterpene mho7 ... See more keywords