Single- and repeated-dose 28-day oral toxicity study of MDM hydantoin in Sprague-Dawley rats.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicological research"
DOI: 10.1007/s43188-020-00055-0
Abstract: 1-(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione (MDM hydantoin) is a commonly used antiseptic preservative in cosmetics. However, limited toxicity information data are available for this chemical. The aim of this study was to obtain toxicity data for MDM hydantoin through… read more here.
Keywords: toxicity study; mdm hydantoin; toxicity; repeated dose ... See more keywords
Mucopenetrating nanoparticles for enhancement of oral bioavailability of furosemide: In vitro and in vivo evaluation/sub-acute toxicity study.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.04.072
Abstract: The aim of this study was to formulate and evaluate chitosan (CS)/alginate (ALG) nanoparticles (NPs) loaded with furosemide (FSM) in an attempt to enhance its release, permeability and bioavailability. Non-everted gut sac method was used… read more here.
Keywords: toxicity study; fsm; bioavailability; study ... See more keywords
Repeated dose 28‐day oral toxicity study of a botanical composition composed of Morus alba and Acacia catechu in rats
Sign Up to like & getrecommendations! Published in 2018 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2018.01.024
Abstract: ABSTRACT Patients with osteoarthritis experience debilitating pain and loss of joint function that requires chronic treatment. While nonsteroidal anti‐inflammatory drugs (NSAIDs) have been effective for temporary symptomatic relief, their long term usage has been limited… read more here.
Keywords: toxicity study; hematology; chemistry; histopathology ... See more keywords
Preclinical Safety Assessment of Chemically Cross-Linked Modified Mandua Starch: Acute and Sub-Acute Oral Toxicity Studies in Swiss Albino Mice
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c01309
Abstract: In the present era, 28 days of repeated-dose-toxicity study following the Organization for Economic Cooperation and Development (OECD) guidelines 407 is compulsory for every drug to go through phase 1 clinical trials. The increasing demand… read more here.
Keywords: mandua starch; cross linked; starch; toxicity ... See more keywords
Preclinical Safety Evaluation: Acute and Repeated-Dose Toxicity of a New Intranasal Recombinant Vector Vaccine TB/FLU-04L Against Tuberculosis.
Sign Up to like & getrecommendations! Published in 2022 at "Drug research"
DOI: 10.1055/a-1771-5985
Abstract: BACKGROUND Vaccination against tuberculosis is one of the most successful medical measures to reduce morbidity and mortality. The BCG vaccine has been in use for more than 100 years, but its efficacy is still controversial.… read more here.
Keywords: toxicity; toxicity study; flu 04l; dose toxicity ... See more keywords
Acute and sub-acute oral toxicity assessment of 5-hydroxy-1,4-naphthoquinone in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2022.2104306
Abstract: 5-hydroxy-1,4-naphthoquinone (5NQ) or juglone is a bioactive molecule found in walnuts and has shown therapeutic effects in various disease models. Limited information is available regarding the toxicity of 5NQ, thereby limiting the clinical development of… read more here.
Keywords: toxicity study; acute toxicity; toxicity; sub acute ... See more keywords
Repeated dose inhalation developmental toxicity study in rats exposed to cellulose insulation with boric acid additive
Sign Up to like & getrecommendations! Published in 2018 at "Inhalation Toxicology"
DOI: 10.1080/08958378.2019.1576806
Abstract: Abstract Cellulose insulation (CI), a common building material, is a mixture of cellulose fibers and borates. Borates are approximately 20% of the product weight and act as a flame retardant. Given possible exposure to workers… read more here.
Keywords: toxicity study; cellulose insulation; toxicity; rats exposed ... See more keywords
Subacute dermal toxicity study of bensulfuron-methyl in Sprague-Dawley rats
Sign Up to like & getrecommendations! Published in 2022 at "Cutaneous and Ocular Toxicology"
DOI: 10.1080/15569527.2022.2077750
Abstract: Abstract Background: Bensulfuron-methyl has recently attracted attention given its widespread use as an herbicide in crops, especially its transdermal safety. However, no dermal toxicity study of this pesticide to mammals has been reported. The present… read more here.
Keywords: bensulfuron methyl; dermal toxicity; toxicity study;
Acute and Subchronic Oral Toxicity Study of Polyherbal Formulation Containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol. ex. Maton in Rats
Sign Up to like & getrecommendations! Published in 2020 at "BioMed Research International"
DOI: 10.1155/2020/8609364
Abstract: The polyherbal formulation containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol ex. Maton has been used for hypertension treatment empirically. Our previous study showed its blood pressure-lowering effect… read more here.
Keywords: polyherbal formulation; roxb; toxicity study; formulation ... See more keywords
Developed meloxicam loaded microparticles for colon targeted delivery: Statistical optimization, physicochemical characterization, and in-vivo toxicity study
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0267306
Abstract: The study aimed to fabricate and evaluate Meloxicam (MLX) loaded Hydroxypropyl Methylcellulose (HPMC) microparticles for colon targeting because MLX is a potent analgesic used in the treatment of pain and inflammation associated with colorectal cancer… read more here.
Keywords: physicochemical characterization; toxicity study; toxicity; drug ... See more keywords
Diligent profiling of preclinical safety of the silk protein sericin
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Basic and Clinical Physiology and Pharmacology"
DOI: 10.1515/jbcpp-2019-0272
Abstract: Abstract Background Sericin is a widely used protein in the pharmaceutical industry derived from the silkworm, Bombyx mori, and used for the treatment of various diseases and pathological conditions. It is the main ingredient of… read more here.
Keywords: toxicity study; sericin; acute toxicity; study ... See more keywords