Regulatory Forum Opinion Piece*: Imaging Applications in Toxicologic Pathology—Recommendations for Use in Regulated Nonclinical Toxicity Studies
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DOI: 10.1177/0192623317710014
Abstract: Available imaging systems for use in preclinical toxicology studies increasingly show utility as important tools in the toxicologic pathologist’s armamentarium, permit longitudinal evaluation of functional and morphological changes in tissues, and provide important information such… read more here.
Keywords: toxicologic pathology; pathology; toxicology; regulatory forum ... See more keywords
Immunohistochemistry in Investigative and Toxicologic Pathology
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DOI: 10.1177/0192623318776907
Abstract: Immunohistochemistry (IHC) is a valuable tool in pathology. This review provides a brief description of the technical aspects of IHC and a detailed discussion on the variables that affect the results, interpretation, and reproducibility of… read more here.
Keywords: immunohistochemistry investigative; investigative toxicologic; toxicologic pathology; pathology ... See more keywords
Statistical Guidance for Reviewers of Toxicologic Pathology
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DOI: 10.1177/0192623318785097
Abstract: Study design, statistical analysis, interpretation of results, and conclusions should be a part of all research papers. Statistics are integral to each of these components and are therefore necessary to evaluate during manuscript peer review.… read more here.
Keywords: research; pathology statistical; toxicologic pathology; statistical guidance ... See more keywords
Toxicologic Pathology Forum*: Opinion on Integrating Innovative Digital Pathology Tools in the Regulatory Framework
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DOI: 10.1177/0192623319827485
Abstract: Digital pathology is defined as the ability to examine digitized microscopic slides and to generate qualitative and quantitative data. The field of digital pathology is rapidly evolving and has the potential to revolutionize toxicologic pathology.… read more here.
Keywords: innovative digital; toxicologic pathology; pathology; digital pathology ... See more keywords
Toxicologic Pathology Forum*: Opinion on Sexual Maturity and Fertility Assessment in Long-tailed Macaques (Macaca fascicularis) in Nonclinical Safety Studies
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DOI: 10.1177/0192623319831009
Abstract: If nonhuman primates represent the only relevant species for nonclinical safety evaluation of biotechnology-derived products, male and female fertility effects can be assessed in repeat dose toxicity studies given that sexually mature monkeys are used.… read more here.
Keywords: sexual maturity; toxicologic pathology; pathology; opinion ... See more keywords
Society of Toxicologic Pathology Digital Pathology and Image Analysis Special Interest Group Article*: Opinion on the Application of Artificial Intelligence and Machine Learning to Digital Toxicologic Pathology
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DOI: 10.1177/0192623319881401
Abstract: Toxicologic pathology is transitioning from analog to digital methods. This transition seems inevitable due to a host of ongoing social and medical technological forces. Of these, artificial intelligence (AI) and in particular machine learning (ML)… read more here.
Keywords: machine learning; article; toxicologic pathology; special interest ... See more keywords
IT/QA and Regulatory Aspects of Digital Pathology: Results of the 8th ESTP International Workshop
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DOI: 10.1177/01926233221113275
Abstract: Digital toxicologic histopathology has been broadly adopted in preclinical compound development for informal consultation and peer review. There is now increased interest in implementing the technology for good laboratory practice–regulated study evaluations. However, the implementation… read more here.
Keywords: aspects digital; toxicologic pathology; pathology; histopathology ... See more keywords
Toxicologic Pathology Forum: A Roadmap for Building State-of-the-Art Digital Image Data Resources for Toxicologic Pathology in the Pharmaceutical Industry
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DOI: 10.1177/01926233221132747
Abstract: Digitization of histologic slides brings with it the promise of enhanced toxicologic pathology practice through the increased application of computational methods. However, the development of these advanced methods requires access to substrate image data, that… read more here.
Keywords: pharmaceutical industry; toxicologic pathology; data resources; pathology ... See more keywords
Book Review: The Illustrated Dictionary of Toxicologic Pathology and Safety Science
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DOI: 10.1177/1091581819880842
Abstract: The work of the toxicologic pathologist is intimately embedded in all aspects of toxicology. Pathology issues pertaining to the development of drugs or other xenobiotics are inherently complex in nature, particularly when they result in… read more here.
Keywords: toxicologic pathology; safety; pathology; book ... See more keywords
Contemporary activities of Toxicologic Pathology Societies
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DOI: 10.1293/tox.2019-0000
Abstract: Educational activities and training opportunities in toxicologic pathology are major goals of 9 formally established Toxicologic Pathology Societies and the International Academy of Toxicologic Pathology. Some Toxicologic Pathology Societies have examination-based certification programs while others… read more here.
Keywords: toxicologic pathology; pathology; pathology societies; activities toxicologic ... See more keywords
The potential of organoids in toxicologic pathology: role of toxicologic pathologists in in vitro chemical hepatotoxicity assessment
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DOI: 10.1293/tox.2022-0017
Abstract: The development of in vitro toxicity assessment methods using cultured cells has gained popularity for promoting animal welfare in animal experiments. Herein, we briefly discuss the current status of hepatoxicity assessment using human- and rat-derived… read more here.
Keywords: vitro chemical; assessment; toxicologic pathologists; toxicologic pathology ... See more keywords