Oncolytic virus preclinical toxicology studies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4408
Abstract: With the ever‐emerging concerns of patient safety during medical care, the search for treatments as safe as possible is a priority, especially when focusing on cancer treatment of which therapies often go hand in hand… read more here.
Keywords: toxicology; oncolytic virus; preclinical toxicology; studies oncolytic ... See more keywords
Harnessing biological applications of quantum materials: opportunities and precautions
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Materials Chemistry C"
DOI: 10.1039/d0tc02429e
Abstract: Since the discovery of graphene, research on two-dimensional (2D) quantum materials has generated a plethora of novel materials with the potential to significantly change our lives. Owing to their unique quantum, electronic, and excitonic properties,… read more here.
Keywords: toxicology studies; biological applications; applications quantum; quantum materials ... See more keywords
Identifying Erythrocyte Injury in Toxicology Studies
Sign Up to like & getrecommendations! Published in 2022 at "Toxicologic Pathology"
DOI: 10.1177/01926233221127942
Abstract: The hematological impacts of a drug can affect erythropoiesis at the level of the bone marrow, or decrease the life span of the RBC (red blood cell). The most common and recognizable clinical manifestation of… read more here.
Keywords: toxicology; toxicology studies; identifying erythrocyte; injury toxicology ... See more keywords
Toxicologic Pathology Forum: Opinion on Approaches for Reporting Toxic and Adverse Dose Levels in Nonclinical Toxicology Studies Supporting the Development of Anticancer Pharmaceuticals.
Sign Up to like & getrecommendations! Published in 2023 at "Toxicologic pathology"
DOI: 10.1177/01926233221146937
Abstract: The advancement of an investigational new drug in humans is a significant developmental milestone. In first-in-human (FIH)-enabling toxicology studies, the highest dose without a test article-related adverse effect (no-observed-adverse-effect-level [NOAEL]) serves as the basis for… read more here.
Keywords: toxicology; anticancer pharmaceuticals; dose; pathology ... See more keywords
Points to Consider in Designing and Conducting Juvenile Toxicology Studies
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Toxicology"
DOI: 10.1177/1091581817699975
Abstract: In support of a clinical trial in the pediatric population, available nonclinical and clinical data provide input on the study design and safety monitoring considerations. When the existing data are lacking to support the safety… read more here.
Keywords: juvenile toxicology; toxicology studies; conducting juvenile; points consider ... See more keywords
“Not Everything That Shakes Is a Seizure”: Making the Determination of Test Article–Induced Convulsions in Toxicology Studies
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Toxicology"
DOI: 10.1177/1091581818796444
Abstract: Spontaneous unexpected events occasionally develop during the course of rodent preclinical toxicology studies. The presentation of serious adverse events on animal studies may require notification of these events to the Food and Drug Administration if… read more here.
Keywords: everything shakes; test article; toxicology; toxicology studies ... See more keywords