Getting a molecule into the clinic: Nonclinical testing and starting dose considerations
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2017.07.027
Abstract: &NA; Examination of content of 35 Investigator Brochures (IBs) for small molecules (including some for oncology) used to support First‐In‐Human studies over a 2 year period (2014–2016) showed that a mean of 37 nonclinical studies… read more here.
Keywords: molecule; starting dose; pharmacology; toxicology testing ... See more keywords
The future of skin toxicology testing – Three-dimensional bioprinting meets microfluidics
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Bioprinting"
DOI: 10.18063/ijb.v5i2.1.237
Abstract: Abstract Over the years, the field of toxicology testing has evolved tremendously from the use of animal models to the adaptation of in vitro testing models. In this perspective article, we aim to bridge the… read more here.
Keywords: three dimensional; testing models; toxicology testing; skin toxicology ... See more keywords