Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I
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DOI: 10.7554/elife.55845
Abstract: Disruption of mitochondrial function selectively targets tumour cells that are dependent on oxidative phosphorylation. However, due to their high energy demands, cardiac cells are disproportionately targeted by mitochondrial toxins resulting in a loss of cardiac… read more here.
Keywords: anti cancer; cancer; mitochondrial respiratory; respiratory complex ... See more keywords