Comparison of Botulinum Toxin A Formulations for Glabellar Strain Treatment in Women: A Double-Blind Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2025.1335
Abstract: Importance Multiple botulinum toxin A formulations were approved by the US Food and Drug Administration for treating the glabellar rhytids. A comparative quantitative evaluation of their effects on the glabella has not been conducted. Objective… read more here.
Keywords: toxin formulations; trial; botulinum toxin; strain ... See more keywords
Death by translation: ribosome‐assisted degradation of mRNA by endonuclease toxins
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12715
Abstract: Like other forms of life, bacteria utilize a variety of mechanisms to survive stress. Some of these mechanisms mitigate the physiological impact of the stress, whereas others enable cells to simply wait out the stressful… read more here.
Keywords: endonuclease; yhav; stress; toxin ... See more keywords
Identification and functional characterization of a bacterial homologue of Zeta toxin in Leishmania donovani
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13429
Abstract: Zeta‐toxin is a cognate toxin of epsilon antitoxin of prokaryotic Type II toxin‐antitoxin system (TA) and play an important role in cell death. An orthologue of bacterial‐zeta‐toxin (BzT) was identified in Leishmania donovani with similar… read more here.
Keywords: leishmania donovani; zeta toxin; toxin; cell death ... See more keywords
Bacterial Toxin‐Responsive Biomimetic Nanobubbles for Precision Photodynamic Therapy against Bacterial Infections
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200698
Abstract: With few options available for the effective treatment of multidrug‐resistant bacteria, photodynamic therapy (PDT) has emerged as a promising therapeutic strategy that does not promote the development of antibiotic resistance. Unfortunately, the beneficial bactericidal effect… read more here.
Keywords: responsive biomimetic; toxin; photodynamic therapy; biomimetic nanobubbles ... See more keywords
Biofilm Microenvironment‐Sensitive Anti‐Virulent and Immunomodulatory Nano‐on‐Nanodroplets to Combat Refractory Biofilm Infection Through Toxin Neutralization and Phagocytosis
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202403528
Abstract: Biofilm‐associated wound infection is principally perceived as the bacterial defense mechanism that hinders antibiotic penetration, causes toxin impairment, and suppresses the immunological responses of the host immune system. Several antibiofilm agents have been developed, but… read more here.
Keywords: anti virulent; biofilm; infection; virulent immunomodulatory ... See more keywords
Engineered Extracellular Vesicles Driven by Erythrocytes Ameliorate Bacterial Sepsis by Iron Recycling, Toxin Clearing and Inflammation Regulation
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202306884
Abstract: Sepsis poses a significant challenge in clinical management. Effective strategies targeting iron restriction, toxin neutralization, and inflammation regulation are crucial in combating sepsis. However, a comprehensive approach simultaneously targeting these multiple processes has not been… read more here.
Keywords: extracellular vesicles; inflammation regulation; iron; toxin ... See more keywords
T‐2 Toxin Exploits Gut‐Derived Staphylococcus Saprophyticus to Disrupt Hepatic Macrophage Homeostasis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202512828
Abstract: T‐2 toxin, a mycotoxin that frequently causes hidden contamination in food and animal feed, poses a substantial threat to both human and animal health. Staphylococcus saprophyticus (S. saprophyticus) is an opportunistic pathogen that widely infects… read more here.
Keywords: macrophage homeostasis; staphylococcus saprophyticus; saprophyticus; toxin ... See more keywords
Development of Peptide Glucosyltransferase Inhibitors With Comprehensive Coverage Across Clostridioides difficile Toxin B Sub-Types.
Sign Up to like & getrecommendations! Published in 2025 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.70102
Abstract: Clostridioides difficile infection presents an escalating clinical challenge due to the proliferation of hypervirulent and antibiotic‐resistant strains. The primary symptoms of disease, namely colitis and diarrhea, are induced by the release of two toxins: TcdA… read more here.
Keywords: clostridioides difficile; development; toxin; development peptide ... See more keywords
High yield purification and first structural characterization of the full‐length bacterial toxin CNF1
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology Progress"
DOI: 10.1002/btpr.2574
Abstract: The Cytotoxic Necrotizing Factor 1 (CNF1) is a bacterial toxin secreted by certain Escherichia coli strains causing severe pathologies, making it a protein of pivotal interest in toxicology. In parallel, the CNF1 capability to influence… read more here.
Keywords: protein; full length; bacterial toxin; toxin ... See more keywords
Endoplasmic reticulum stress is involved in the T‐2 toxin‐induced apoptosis in goat endometrium epithelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3655
Abstract: T‐2 toxin is one of the trichothecene mycotoxins commonly found in animal feed and agricultural products. Ingestion of T‐2 toxin by animals results in acute and chronic diseases, as well as reproductive failure. This study… read more here.
Keywords: epithelial cells; endometrium epithelial; apoptosis; induced apoptosis ... See more keywords
Enhanced In Vivo Tetanus Toxin Neutralizing Potency of an Anti‐Toxin Monoclonal Antibody Following Antibody Chimerization
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70595
Abstract: Each immunoglobulin molecule consists of two functional independent regions, including variable and constant regions. Toxin neutralization by antibody is mainly mediated by the variable regions. Here, we report that constant region chimerization of a mouse… read more here.
Keywords: antibody; tetanus toxin; mab; toxin neutralizing ... See more keywords