Genome wide screening to discover novel toxin–antitoxin modules in Mycobacterium indicus pranii; perspective on gene acquisition during mycobacterial evolution
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2651
Abstract: Mycobacterium indicus pranii (MIP), a benign saprophyte with potent immunomodulatory attributes, holds a pivotal position in mycobacterial evolution, potentially serving as the precursor to the pathogenic Mycobacterium avium complex (MAC). Despite its established immunotherapeutic efficacy… read more here.
Keywords: genome wide; toxin antitoxin; indicus pranii; mycobacterium indicus ... See more keywords
Evolutionary history of Caulobacter toxin-antitoxin systems.
Sign Up to like & getrecommendations! Published in 2021 at "Current microbiology"
DOI: 10.1007/s00284-021-02549-y
Abstract: Toxin-antitoxin (TA) systems have been studied in many bacterial genera, but a clear understanding of the evolutionary trajectory of TA operons has not emerged. To address this issue, I identified 42 distinct TA operons in… read more here.
Keywords: toxin antitoxin; location; antitoxin systems; caulobacter ... See more keywords
In Silico Derived Peptides for Inhibiting the Toxin–Antitoxin Systems of Mycobacterium tuberculosis: Basis for Developing Peptide-Based Therapeutics
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-018-9792-8
Abstract: Toxin–antitoxin (TA) systems of Mycobacterium tuberculosis (Mtb) is a prerequisite for the bacterium to survive in extreme conditions. Antimicrobial peptides inhibiting the formation of these complexes provide a novel strategy for TB drug discovery process.… read more here.
Keywords: antitoxin systems; systems mycobacterium; derived peptides; silico derived ... See more keywords
In Silico Insight into the Dominant Type II Toxin–Antitoxin Systems and Clp Proteases in Listeria monocytogenes and Designation of Derived Peptides as a Novel Approach to Interfere with this System
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-019-09868-6
Abstract: Persisters are a variant of bacteria responsible for non-inherited antibiotic resistance and tolerance. Listeria monocytogenes is a predominant food-borne pathogen causing listeriosis. Persister cell formation in L. monocytogenes population may be explained by the presence… read more here.
Keywords: antitoxin; novel approach; antitoxin systems; toxin antitoxin ... See more keywords
Functional and structural characterization of Deinococcus radiodurans R1 MazEF toxin-antitoxin system, Dr0416-Dr0417
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Microbiology"
DOI: 10.1007/s12275-021-0523-z
Abstract: In prokaryotes, toxin-antitoxin (TA) systems are commonly found. They likely reflect the adaptation of pathogenic bacteria or extremophiles to various unfavorable environments by slowing their growth rate. Genomic analysis of the extremophile Deinococcus radiodurans R1… read more here.
Keywords: deinococcus radiodurans; toxin antitoxin; maze mazf; mazf ... See more keywords
GhoT of the GhoT/GhoS toxin/antitoxin system damages lipid membranes by forming transient pores.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.01.067
Abstract: GhoT is a bacterial toxin of the type V toxin/antitoxin system that allows Escherichia coli to reduce its metabolism in response to oxidative and bile stress. GhoT functions by increasing membrane permeability and reducing both… read more here.
Keywords: toxin antitoxin; toxin; forming transient; antitoxin system ... See more keywords
Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.05.028
Abstract: Toxin-antitoxin (TA) systems are ubiquitous genetic elements in bacterial genomes, but their functions are controversial. Although they are frequently postulated to regulate cell growth following stress, few null phenotypes for TA systems have been reported.… read more here.
Keywords: transcription; antitoxin systems; stress; toxin ... See more keywords
Engineered Vibrio natriegens with a Toxin-Antitoxin System for High-Productivity Biotransformation of l-Lysine to Cadaverine.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c12616
Abstract: Vibrio natriegens, a fast-growing bacterium, is an emerging chassis of next-generation industrial biotechnology capable of thriving under open and continuous culture conditions. Cadaverine, a valuable industrial C5 platform chemical, has various chemical and biological activities.… read more here.
Keywords: toxin antitoxin; antitoxin system; cadaverine; lysine ... See more keywords
Crosstalk between inovirus core gene and accessory toxin-antitoxin system mediates polylysogeny
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-62378-6
Abstract: Polylysogeny, the harboring of multiple prophages within a single bacterial genome, is common among bacterial pathogens and enhances virulence and genome plasticity. Inoviruses (filamentous phages) are often present in multiple copies in major pathogens, leading… read more here.
Keywords: core; antitoxin; toxin antitoxin; crosstalk ... See more keywords
Mechanisms of neutralization of toxSAS from toxin–antitoxin modules
Sign Up to like & getrecommendations! Published in 2024 at "Nature Chemical Biology"
DOI: 10.1038/s41589-024-01630-4
Abstract: Toxic small alarmone synthetase (toxSAS) enzymes constitute a family of bacterial effectors present in toxin–antitoxin and secretion systems. toxSASs act through either translation inhibition mediated by pyrophosphorylation of transfer RNA (tRNA) CCA ends or synthesis… read more here.
Keywords: neutralization; toxin antitoxin; antitoxin modules; toxin ... See more keywords
Identification of novel mazEF/pemIK family toxin-antitoxin loci and their distribution in the Staphylococcus genus
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13857-4
Abstract: The versatile roles of toxin-antitoxin (TA) systems in bacterial physiology and pathogenesis have been investigated for more than three decades. Diverse TA loci in Bacteria and Archaea have been identified in genome-wide studies. The advent… read more here.
Keywords: mazef pemik; distribution; novel mazef; pemik family ... See more keywords