Evolutionary history of Caulobacter toxin-antitoxin systems.
Sign Up to like & getrecommendations! Published in 2021 at "Current microbiology"
DOI: 10.1007/s00284-021-02549-y
Abstract: Toxin-antitoxin (TA) systems have been studied in many bacterial genera, but a clear understanding of the evolutionary trajectory of TA operons has not emerged. To address this issue, I identified 42 distinct TA operons in… read more here.
Keywords: toxin antitoxin; location; antitoxin systems; caulobacter ... See more keywords
In Silico Derived Peptides for Inhibiting the Toxin–Antitoxin Systems of Mycobacterium tuberculosis: Basis for Developing Peptide-Based Therapeutics
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-018-9792-8
Abstract: Toxin–antitoxin (TA) systems of Mycobacterium tuberculosis (Mtb) is a prerequisite for the bacterium to survive in extreme conditions. Antimicrobial peptides inhibiting the formation of these complexes provide a novel strategy for TB drug discovery process.… read more here.
Keywords: antitoxin systems; systems mycobacterium; derived peptides; silico derived ... See more keywords
In Silico Insight into the Dominant Type II Toxin–Antitoxin Systems and Clp Proteases in Listeria monocytogenes and Designation of Derived Peptides as a Novel Approach to Interfere with this System
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-019-09868-6
Abstract: Persisters are a variant of bacteria responsible for non-inherited antibiotic resistance and tolerance. Listeria monocytogenes is a predominant food-borne pathogen causing listeriosis. Persister cell formation in L. monocytogenes population may be explained by the presence… read more here.
Keywords: antitoxin; novel approach; antitoxin systems; toxin antitoxin ... See more keywords
Functional and structural characterization of Deinococcus radiodurans R1 MazEF toxin-antitoxin system, Dr0416-Dr0417
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Microbiology"
DOI: 10.1007/s12275-021-0523-z
Abstract: In prokaryotes, toxin-antitoxin (TA) systems are commonly found. They likely reflect the adaptation of pathogenic bacteria or extremophiles to various unfavorable environments by slowing their growth rate. Genomic analysis of the extremophile Deinococcus radiodurans R1… read more here.
Keywords: deinococcus radiodurans; toxin antitoxin; maze mazf; mazf ... See more keywords
GhoT of the GhoT/GhoS toxin/antitoxin system damages lipid membranes by forming transient pores.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.01.067
Abstract: GhoT is a bacterial toxin of the type V toxin/antitoxin system that allows Escherichia coli to reduce its metabolism in response to oxidative and bile stress. GhoT functions by increasing membrane permeability and reducing both… read more here.
Keywords: toxin antitoxin; toxin; forming transient; antitoxin system ... See more keywords
Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.05.028
Abstract: Toxin-antitoxin (TA) systems are ubiquitous genetic elements in bacterial genomes, but their functions are controversial. Although they are frequently postulated to regulate cell growth following stress, few null phenotypes for TA systems have been reported.… read more here.
Keywords: transcription; antitoxin systems; stress; toxin ... See more keywords
Identification of novel mazEF/pemIK family toxin-antitoxin loci and their distribution in the Staphylococcus genus
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13857-4
Abstract: The versatile roles of toxin-antitoxin (TA) systems in bacterial physiology and pathogenesis have been investigated for more than three decades. Diverse TA loci in Bacteria and Archaea have been identified in genome-wide studies. The advent… read more here.
Keywords: mazef pemik; distribution; novel mazef; pemik family ... See more keywords
ClpAP protease is a universal factor that activates the parDE toxin-antitoxin system from a broad host range RK2 plasmid
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33726-y
Abstract: The activity of type II toxin-antitoxin systems (TA), which are responsible for many important features of bacterial cells, is based on the differences between toxin and antitoxin stabilities. The antitoxin lability results from bacterial protease… read more here.
Keywords: toxin antitoxin; toxin; antitoxin; clpap protease ... See more keywords
Why so narrow: Distribution of anti-sense regulated, type I toxin-antitoxin systems compared with type II and type III systems
Sign Up to like & getrecommendations! Published in 2017 at "RNA Biology"
DOI: 10.1080/15476286.2016.1272747
Abstract: ABSTRACT Toxin-antitoxin (TA) systems are gene modules that appear to be horizontally mobile across a wide range of prokaryotes. It has been proposed that type I TA systems, with an antisense RNA-antitoxin, are less mobile… read more here.
Keywords: antitoxin systems; toxin; type; toxin antitoxin ... See more keywords
Comparative analysis of MazEF and HicAB toxin–antitoxin systems of the cyanobacterium, Anabaena sp. PCC7120
Sign Up to like & getrecommendations! Published in 2017 at "FEMS Microbiology Letters"
DOI: 10.1093/femsle/fnw279
Abstract: &NA; Anabaena PCC7120 has two annotated toxin–antitoxin systems: MazEF and HicAB. Overexpression of either of the toxins severely inhibited the growth of Escherichia coli BL21(plysS)(DE3). Of the two Anabaena toxins, MazF exhibited higher toxicity than… read more here.
Keywords: anabaena pcc7120; toxin; mazef hicab; toxin antitoxin ... See more keywords
Tuning the expression of the bacterial relBE toxin-antitoxin system in Saccharomyces cerevisiae allows characterizing the subsequent growth inhibition.
Sign Up to like & getrecommendations! Published in 2023 at "FEMS yeast research"
DOI: 10.1093/femsyr/foad009
Abstract: The bacterial toxin-antitoxin systems are each composed of a toxin, which severely inhibits bacterial cells growth, and a specific neutralizing antitoxin. Some toxin-antitoxin systems are functional when expressed in the yeast Saccharomyces cerevisiae. For instance,… read more here.
Keywords: toxin antitoxin; system; growth; expression ... See more keywords