Small-Molecule Allosteric Triggers of Clostridium difficile Toxin B Auto-proteolysis as a Therapeutic Strategy.
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DOI: 10.1016/j.chembiol.2018.10.002
Abstract: Clostridium difficile causes increasing numbers of life-threatening intestinal infections. Symptoms associated with C. difficile infection (CDI) are mediated by secreted protein toxins, whose virulence is modulated by intracellular auto-proteolysis following allosteric activation of their protease domains… read more here.
Keywords: auto; clostridium difficile; toxin auto; difficile toxin ... See more keywords