Crystal structure of ricin toxin A chain complexed with a highly potent pterin-based small-molecular inhibitor
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2219038
Abstract: Abstract Ricin toxin A chain (RTA), from Ricinus communis, is a deadly protein that inactivates ribosomes by degrading an adenine residue at position 4324 in 28S rRNA. Recently, we have demonstrated that pterin-7-carboxamides with peptide… read more here.
Keywords: toxin chain; rta; crystal structure; ricin toxin ... See more keywords
Pterin-based small molecule inhibitor capable of binding to the secondary pocket in the active site of ricin-toxin A chain
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0277770
Abstract: The Ricin toxin A chain (RTA), which depurinates an adenine base at a specific region of the ribosome leading to death, has two adjacent specificity pockets in its active site. Based on this structural information,… read more here.
Keywords: active site; small molecule; ricin toxin; toxin chain ... See more keywords