Utilizing in silico and in vitro methods to identify possible binding sites of a novel ligand against Pseudomonas aeruginosa phospholipase toxin ExoU
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.101188
Abstract: Multi-drug resistant infections caused by the opportunistic pathogen, Pseudomonas aeruginosa (P. aeruginosa), are a continuing problem that contribute to morbidity and mortality in immunocompromised hosts such as cystic fibrosis (CF), wound and burn patients. The… read more here.
Keywords: toxin exou; possible binding; identify possible; novel ligand ... See more keywords
The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24337-9
Abstract: Pseudomonas aeruginosa can cause nosocomial infections, especially in ventilated or cystic fibrosis patients. Highly pathogenic isolates express the phospholipase ExoU, an effector of the type III secretion system that acts on plasma membrane lipids, causing… read more here.
Keywords: requires host; exou; bacterial toxin; exou requires ... See more keywords