Multidrug and toxin extrusion protein 1-mediated interaction of metformin and Scutellariae radix in rats
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DOI: 10.1080/00498254.2016.1257836
Abstract: Abstract 1. The metformin and Scutellariae radix extract (SB) combination has been previously reported to enhance anti-diabetic activity. Considering that organic cation transporters (OCTs) and multi-drug and toxin extrusion proteins (MATEs) in the liver and kidney… read more here.
Keywords: scutellariae radix; metformin scutellariae; metformin; toxin extrusion ... See more keywords
Impact of Direction of Transport on the Evaluation of Substrate Recognition of Mouse Multidrug and Toxin Extrusion Protein 1
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DOI: 10.1124/dmd.122.001115
Abstract: Multidrug and toxin extrusion protein (MATE/SLC47A) secretes metabolites and xenobiotics into the urine in the proximal tubules of the kidney. Uptake assays have been commonly used for evaluating MATE-mediated transport of new chemical entities in… read more here.
Keywords: toxin extrusion; kidney; drug; multidrug toxin ... See more keywords