Endoplasmic reticulum stress is involved in the T‐2 toxin‐induced apoptosis in goat endometrium epithelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3655
Abstract: T‐2 toxin is one of the trichothecene mycotoxins commonly found in animal feed and agricultural products. Ingestion of T‐2 toxin by animals results in acute and chronic diseases, as well as reproductive failure. This study… read more here.
Keywords: epithelial cells; endometrium epithelial; apoptosis; induced apoptosis ... See more keywords
Toxin-induced hormesis may restrain aging
Sign Up to like & getrecommendations! Published in 2019 at "Biogerontology"
DOI: 10.1007/s10522-019-09806-5
Abstract: Mild environmental stress might have beneficial effects in aging by activating maintenance and repair processes in cells and organs. These beneficial stress effects fit to the concept of hormesis. Prominent stressors acting in a hormetic… read more here.
Keywords: signaling pathways; hormesis; toxin induced; hormesis may ... See more keywords
l-arginine protects against T-2 toxin-induced male reproductive impairments in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2018.12.024
Abstract: l-arginine is beneficial for reproductive health; however, whether l-arginine may confer protection against T-2 toxin-induced reproductive impairment is not known. To address this, we used a mice model treated with T-2 toxin to investigate protective… read more here.
Keywords: reproductive impairments; impairments mice; arginine; male reproductive ... See more keywords
Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Immunity"
DOI: 10.1128/iai.00153-22
Abstract: C. difficile infection (CDI) is a highly inflammatory disease mediated by the production of two large toxins that weaken the intestinal epithelium and cause extensive colonic tissue damage. Antibiotic alternative therapies for CDI are urgently… read more here.
Keywords: disease; toxin; bile acids; toxin induced ... See more keywords
Intraluminal Administration of Resiniferatoxin Protects against Clostridium difficile Toxin A-Induced Colitis
Sign Up to like & getrecommendations! Published in 2017 at "Gastroenterology Research and Practice"
DOI: 10.1155/2017/8438172
Abstract: Clostridium difficile toxin A is a colonic inflammatory agent that acts partially by activation of TRPV1 (transient receptor potential vanilloid type 1). Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes… read more here.
Keywords: clostridium difficile; difficile toxin; toxin; rtx ... See more keywords
Knockdown of the mitochondria‐localized protein p13 protects against experimental parkinsonism
Sign Up to like & getrecommendations! Published in 2018 at "EMBO reports"
DOI: 10.15252/embr.201744860
Abstract: Mitochondrial dysfunction in the nigrostriatal dopaminergic system is a critical hallmark of Parkinson's disease (PD). Mitochondrial toxins produce cellular and behavioural dysfunctions resembling those in patients with PD. Causative gene products for familial PD play… read more here.
Keywords: mitochondria localized; protein p13; knockdown mitochondria; toxin induced ... See more keywords
The American Cockroach Peptide Periplanetasin-2 Blocks Clostridium Difficile Toxin A-Induced Cell Damage and Inflammation in the Gut.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.1612.12012
Abstract: Clostridium difficile, which causes pseudomembranous colitis, releases toxin A and toxin B. These toxins are considered to be the main causative agents for the disease pathogenesis, and their expression is associated with a marked increase… read more here.
Keywords: inflammation; difficile toxin; toxin; toxin induced ... See more keywords
Decreased S100A9 expression alleviates Clostridium perfringens beta2 toxin-induced inflammatory injury in IPEC-J2 cells
Sign Up to like & getrecommendations! Published in 2023 at "PeerJ"
DOI: 10.7717/peerj.14722
Abstract: Background S100 calcium-binding protein A9 (S100A9) is a commonly known pro-inflammatory factor involved in various inflammatory responses. Clostridium perfringens (C. perfringens ) type C is known to cause diarrhea in piglets. However, the role of… read more here.
Keywords: expression; ipec cells; toxin; injury ... See more keywords