Comparative assessment of the VH-VL and VL-VH orientations of single-chain variable fragments of scorpion toxin-neutralizing antibodies.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.04.015
Abstract: The present study evaluated the effect of the change in the orientation of the VH-VL variable domains to VL-VH on the physicochemical and functional properties of two scorpion toxin-neutralizing scFvs. The results showed that the… read more here.
Keywords: assessment orientations; toxin neutralizing; scorpion toxin; comparative assessment ... See more keywords
Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies
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DOI: 10.1128/iai.00292-20
Abstract: Typhoid toxin is a virulence factor of Salmonella enterica serovar Typhi, the causative agent of typhoid fever, and is thought to be responsible for the symptoms of severe disease. This toxin has a unique A2B5… read more here.
Keywords: monoclonal antibodies; toxin neutralizing; toxin; generation characterization ... See more keywords
A Supercluster of Neutralizing Epitopes at the Interface of Ricin’s Enzymatic (RTA) and Binding (RTB) Subunits
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DOI: 10.3390/toxins9120378
Abstract: As part of an effort to engineer ricin antitoxins and immunotherapies, we previously produced and characterized a collection of phage-displayed, heavy chain-only antibodies (VHHs) from alpacas that had been immunized with ricin antigens. In our… read more here.
Keywords: rtb; ricin; rta; toxin ... See more keywords