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   Articles with "toxin neutralizing" as a keyword



Enhanced In Vivo Tetanus Toxin Neutralizing Potency of an Anti‐Toxin Monoclonal Antibody Following Antibody Chimerization

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recommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.70595

Abstract: Each immunoglobulin molecule consists of two functional independent regions, including variable and constant regions. Toxin neutralization by antibody is mainly mediated by the variable regions. Here, we report that constant region chimerization of a mouse… read more here.

Keywords: antibody; tetanus toxin; mab; toxin neutralizing ... See more keywords

Comparative assessment of the VH-VL and VL-VH orientations of single-chain variable fragments of scorpion toxin-neutralizing antibodies.

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recommendations! Published in 2020 at "Molecular immunology"

DOI: 10.1016/j.molimm.2020.04.015

Abstract: The present study evaluated the effect of the change in the orientation of the VH-VL variable domains to VL-VH on the physicochemical and functional properties of two scorpion toxin-neutralizing scFvs. The results showed that the… read more here.

Keywords: assessment orientations; toxin neutralizing; scorpion toxin; comparative assessment ... See more keywords

Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies

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recommendations! Published in 2020 at "Infection and Immunity"

DOI: 10.1128/iai.00292-20

Abstract: Typhoid toxin is a virulence factor of Salmonella enterica serovar Typhi, the causative agent of typhoid fever, and is thought to be responsible for the symptoms of severe disease. This toxin has a unique A2B5… read more here.

Keywords: monoclonal antibodies; toxin neutralizing; toxin; generation characterization ... See more keywords

Toxin-neutralizing Abs are associated with improved T cell function following recovery from Staphylococcus aureus infection

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recommendations! Published in 2024 at "JCI Insight"

DOI: 10.1172/jci.insight.173526

Abstract: BACKGROUND T cell responses are impaired in Staphylococcus aureus–infected children, highlighting a potential mechanism of immune evasion. This study tested the hypotheses that toxin-specific antibodies protect immune cells from bacterial killing and are associated with… read more here.

Keywords: cell function; cell; infection; toxin neutralizing ... See more keywords

A Supercluster of Neutralizing Epitopes at the Interface of Ricin’s Enzymatic (RTA) and Binding (RTB) Subunits

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recommendations! Published in 2017 at "Toxins"

DOI: 10.3390/toxins9120378

Abstract: As part of an effort to engineer ricin antitoxins and immunotherapies, we previously produced and characterized a collection of phage-displayed, heavy chain-only antibodies (VHHs) from alpacas that had been immunized with ricin antigens. In our… read more here.

Keywords: rtb; ricin; rta; toxin ... See more keywords