Quantitative interpretation of ToxTracker dose–response data for potency comparisons and mode‐of‐action determination
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DOI: 10.1002/em.22525
Abstract: ToxTracker is an in vitro mammalian stem cell‐based reporter assay that detects activation of specific cellular signaling pathways (DNA damage, oxidative stress, and/or protein damage) upon chemical exposure using flow cytometry. Here we used quantitative… read more here.
Keywords: stress; potency; response data; dose response ... See more keywords
Utility of ToxTracker in animal alternative testing strategy for fragrance materials
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DOI: 10.1002/em.22532
Abstract: To determine the utility of the ToxTracker assay in animal alternative testing strategies, the genotoxic potential of four fragrance materials (2‐octen‐4‐one, lauric aldehyde, veratraldehyde, and p‐methoxy cinnamaldehyde) were tested in the ToxTracker assay. These materials… read more here.
Keywords: toxtracker assay; toxtracker; animal alternative; utility toxtracker ... See more keywords