Concordance between TP53 alterations in blood and tissue: impact of time interval, biopsy site, cancer type and circulating tumor DNA burden
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12672
Abstract: We examined the impact of spatial, temporal, histologic, and quantitative factors on concordance between TP53 alterations in tissue DNA vs in circulating tumor DNA (ctDNA). Four hundred and thirty‐three patients underwent next‐generation sequencing (NGS) in… read more here.
Keywords: tp53 alterations; dna; concordance; tissue ... See more keywords
Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT
Sign Up to like & getrecommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-022-00924-0
Abstract: TP53 gene alteration confers inferior prognosis in refractory/relapse aggressive B-cell non-Hodgkin lymphoma (r/r B-NHL). From September 2016 to September 2020, 257 r/r B-NHL patients were assessed for eligibility for two trials in our center, assessing… read more here.
Keywords: combination; tp53 alterations; aggressive cell; car19 cell ... See more keywords
TRK Protein Expression in TP53 Altered Acute Erythroid Leukemia
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DOI: 10.1182/blood-2024-211201
Abstract: Introduction: Acute erythroid leukemia (AEL; also called pure erythroid leukemia or PEL) is characterized by a neoplastic proliferation of erythroid elements with maturation arrest and 30% or greater proerythroblasts. AEL is associated with multi-hit alterations… read more here.
Keywords: expression; trk; tp53 alterations; erythroid leukemia ... See more keywords
The Putative Role of TP53 Alterations and p53 Expression in Borderline Ovarian Tumors - Correlation with Clinicopathological Features and Prognosis: A Mini-Review
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DOI: 10.7150/jca.19691
Abstract: Borderline ovarian tumors (BOTs) represent an independent group among ovarian malignancies, being diagnosed at clinical stage earlier than invasive ovarian carcinomas (OCs) and characterized by a rather favorable outcome after careful surgical management. Data published… read more here.
Keywords: ovarian tumors; tp53 alterations; borderline ovarian; expression ... See more keywords