Mutation profiling in the PIK3CA, TP53, and CDKN2A genes in circulating free DNA and impalpable breast lesions.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2018.12.008
Abstract: Breast impalpable lesions have become a clinical dilemma because they are small, presenting a heterogeneous cellular phenotype. The aim of this study was to evaluate the mutational profile of the PIK3CA, TP53, and CDKN2A genes,… read more here.
Keywords: tp53 cdkn2a; cdkn2a genes; pik3ca tp53; breast ... See more keywords
Assessment of TP53 and CDKN2A status as predictive markers of malignant transformation of sinonasal inverted papilloma
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-64901-z
Abstract: The mechanism and predictive biomarkers of sinonasal inverted papilloma (IP) transformation into squamous cell carcinoma (SCC) are still unclear. We investigated the genetic mutations involved and the predictive biomarkers. Fourteen patients with SCC arising from… read more here.
Keywords: malignant transformation; cdkn2a status; transformation; tp53 cdkn2a ... See more keywords
Generation and multiomic profiling of a TP53/CDKN2A double-knockout gastroesophageal junction organoid model
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abq6146
Abstract: Inactivation of the tumor suppressor genes tumor protein p53 (TP53) and cyclin-dependent kinase inhibitor 2A (CDKN2A) occurs early during gastroesophageal junction (GEJ) tumorigenesis. However, because of a paucity of GEJ-specific disease models, cancer-promoting consequences of… read more here.
Keywords: gej; gastroesophageal junction; tp53 cdkn2a; model ... See more keywords
Abstract B40: Minimal mutational determinants of human squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.camodels2020-b40
Abstract: Dozens of driver mutations and copy number changes have been implicated in human squamous cell carcinomas (SCCs), and each tumor harbors multiple putative driver mutations. However, the minimal set of mutations sufficient to transform a… read more here.
Keywords: human squamous; cell carcinoma; squamous cell; tp53 cdkn2a ... See more keywords
Concurrent loss of TP53 and CDKN2A with tetraploidy predicts richter transformation and poor prognosis in chronic lymphocytic leukemia
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DOI: 10.1182/blood-2025-2133
Abstract: Background: Richter transformation (RT) can occur in 2-20% chronic lymphocytic leukemia (CLL) patients and has a poor prognosis with a median overall survival (OS) of less than one year. RT is associated with increased chromosome… read more here.
Keywords: tetraploidy detection; loss; tp53; tp53 cdkn2a ... See more keywords