Mutation profiling in the PIK3CA, TP53, and CDKN2A genes in circulating free DNA and impalpable breast lesions.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2018.12.008
Abstract: Breast impalpable lesions have become a clinical dilemma because they are small, presenting a heterogeneous cellular phenotype. The aim of this study was to evaluate the mutational profile of the PIK3CA, TP53, and CDKN2A genes,… read more here.
Keywords: tp53 cdkn2a; cdkn2a genes; pik3ca tp53; breast ... See more keywords
Generation and multiomic profiling of a TP53/CDKN2A double-knockout gastroesophageal junction organoid model
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abq6146
Abstract: Inactivation of the tumor suppressor genes tumor protein p53 (TP53) and cyclin-dependent kinase inhibitor 2A (CDKN2A) occurs early during gastroesophageal junction (GEJ) tumorigenesis. However, because of a paucity of GEJ-specific disease models, cancer-promoting consequences of… read more here.
Keywords: gej; gastroesophageal junction; tp53 cdkn2a; model ... See more keywords
Abstract B40: Minimal mutational determinants of human squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.camodels2020-b40
Abstract: Dozens of driver mutations and copy number changes have been implicated in human squamous cell carcinomas (SCCs), and each tumor harbors multiple putative driver mutations. However, the minimal set of mutations sufficient to transform a… read more here.
Keywords: human squamous; cell carcinoma; squamous cell; tp53 cdkn2a ... See more keywords