Clinical characteristics and overall survival among acute myeloid leukemia patients with TP53 gene mutation or chromosome 17p deletion.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of hematology"
DOI: 10.1002/ajh.26941
Abstract: Approximately 5% to 15% of acute myeloid leukemia (AML) patients have TP53 gene mutations (TP53m), which are associated with very poor outcomes. Adults (≥18 years) with a new AML diagnosis were included from a nationwide, de-identified,… read more here.
Keywords: myeloid leukemia; tp53 gene; patients tp53; acute myeloid ... See more keywords
Full-length mutation search of the TP53 gene in acute myeloid leukemia has increased significance as a prognostic factor
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Hematology"
DOI: 10.1007/s00277-017-3143-2
Abstract: TP53 gene abnormality has been reported to be an unfavorable prognostic factor in acute myeloid leukemia (AML). However, almost all studies of TP53 gene abnormality so far have been limited to mutation searches in the… read more here.
Keywords: gene; prognostic factor; tp53 gene; mutation ... See more keywords
TP53 gene status is a critical determinant of phenotypes induced by ALKBH3 knockdown in non-small cell lung cancers.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.05.024
Abstract: Human AlkB homolog 3 (ALKBH3) is overexpressed in non-small cell lung cancers (NSCLC) and its high expression is significantly correlated with poor prognosis. While ALKBH3 knockdown induces apoptosis in NSCLC cells, the underlying anti-apoptotic mechanisms… read more here.
Keywords: gene status; alkbh3 knockdown; tp53 gene; induced alkbh3 ... See more keywords
Impact of TP53 gene variants on prognosis and survival of childhood acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2023 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2023.2195682
Abstract: Abstract The tumor suppressor protein 53 (TP53) gene is one of the most studied genes in cancer. Although TP53 variants are rare events in acute leukemia, recent observations showed that relapse samples might harbor TP53… read more here.
Keywords: tp53 variants; tp53 gene; leukemia; childhood acute ... See more keywords
Mutation of the TP53 Gene in Placental Chorangiomatosis
Sign Up to like & getrecommendations! Published in 2023 at "Fetal and Pediatric Pathology"
DOI: 10.1080/15513815.2022.2161330
Abstract: Abstract Objective: We explored the frequency of TP53 gene mutations in chorangiomas (CA) and chorangiomatosis (CM). Materials and methods: By Sanger sequencing, we evaluated mutations in exons 4-6 of the TP53 gene in CM and… read more here.
Keywords: chorangiomatosis; mutation tp53; tp53; tp53 gene ... See more keywords
P173 Plasma and tumour tissue TP53-gene expression in patients with high grade serous advanced ovarian cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-esgo.233
Abstract: Introduction/Background TP53 is a tumour suppressor gene frequently mutated in high grade serous ovarian cancer(HGSOC).The aim of this study is to investigate the expression of TP5-gene in cell-free DNA(cfDNA) in plasma and tumour paraffin-embedded tissue… read more here.
Keywords: tumour tissue; expression; tissue; tp53 gene ... See more keywords
Clinical aspects of TP53 gene inactivation in diffuse large B-cell lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "BMC Medical Genomics"
DOI: 10.1186/s12920-019-0484-9
Abstract: BackgroundThe knowledge about specific mechanisms generating TP53 dysfunction in diffuse large B-cell lymphoma is limited. The aim of the current study was to comprehensively explore TP53 gene variability resulting from somatic mutations, promoter methylation, and… read more here.
Keywords: cell; tp53 gene; large cell; gene ... See more keywords
Significance of testing for TP53 gene mutations in lung adenocarcinoma using targeted gene sequencing.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2018.10.66
Abstract: Randomized clinical trials have demonstrated the positive effects of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) for patients with advanced or recurrent lung adenocarcinomas harboring EGFR gene mutations (1-3). Detecting cancer-specific gene mutations and exploring… read more here.
Keywords: gene mutations; mutations lung; significance testing; tp53 gene ... See more keywords
Analysis of cell-free DNA concentration, fragmentation patterns and TP53 gene expression in mammary tumor-bearing dogs: A pilot study
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2023.1157878
Abstract: Introduction Liquid biopsy based on the analysis of circulating cell-free DNA (cfDNA), as well as on detection of point mutations by digital droplet PCR (ddPCR), has revolutionized the research in oncology. In recent years, this… read more here.
Keywords: oncology; tp53 gene; concentration; expression ... See more keywords
Sensitive Electrochemical Biosensor for Rapid Screening of Tumor Biomarker TP53 Gene Mutation Hotspot
Sign Up to like & getrecommendations! Published in 2022 at "Biosensors"
DOI: 10.3390/bios12080658
Abstract: Rapid and sensitive detection of cancer biomarkers is crucial for cancer screening, early detection, and improving patient survival rate. The present study proposes an electrochemical gene-sensor capable of detecting tumor related TP53 gene mutation hotspots… read more here.
Keywords: gene mutation; biosensor; tp53 gene; detection ... See more keywords
TP53 Gene Therapy as a Potential Treatment for Patients with COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14040739
Abstract: SGT-53 is a novel investigational agent that comprises an immunoliposome carrying a plasmid vector driving expression of the human TP53 gene that encodes wild-type human p53. SGT-53 is currently in phase II human trials for… read more here.
Keywords: therapy potential; tp53 gene; gene therapy; p53 ... See more keywords