What is the significance of TP53 and KRAS mutation for immunotherapy in non-small cell lung cancer?
Sign Up to like & getrecommendations! Published in 2017 at "Translational cancer research"
DOI: 10.21037/14120
Abstract: Increasing evidences including PD-L1 expression (1,2), tumor mutation burden (TMB) (3,4), and the intensity of CD8+ T cell infiltrates (5-7) have been respectively certified as predictive biomarkers of response to immunotherapy. More recently, our study… read more here.
Keywords: kras mutation; tp53 kras; lung cancer; cell ... See more keywords
TP53 /KRAS Co-Mutations Create Divergent Prognosis Signatures in Intrahepatic Cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.844800
Abstract: Background: Due to high invasiveness and heterogeneity, the morbidity and mortality of intrahepatic cholangiocarcinoma (ICC) remain unsatisfied. Recently, the exploration of genomic variants has decoded the underlying mechanisms of initiation and progression for multiple tumors,… read more here.
Keywords: intrahepatic cholangiocarcinoma; mutation; tp53 kras; prognosis ... See more keywords