Polymorphisms in apoptosis-related genes in cutaneous melanoma prognosis: sex disparity
Sign Up to like & getrecommendations! Published in 2017 at "Medical Oncology"
DOI: 10.1007/s12032-016-0868-z
Abstract: Cutaneous melanoma (CM) cells are resistant to apoptosis, and steroid hormones are involved in this process through regulation of TP53, MDM2, BAX, and BCL2 expression. We analyzed herein sex differences in outcomes of CM patients… read more here.
Keywords: melanoma; tp53 mdm2; cutaneous melanoma; sex ... See more keywords
Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0283-3
Abstract: The TP53-MDM2-AR-AKT signalling network plays a critical role in the development and progression of prostate cancer. However, the molecular mechanisms regulating this signalling network are not completely defined. By conducting transcriptome analysis, denaturing immunoprecipitations and… read more here.
Keywords: cancer; tp53 mdm2; mdm2 akt; signalling network ... See more keywords
Splicing factor DHX15 affects tp53 and mdm2 expression via alternate splicing and promoter usage.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz261
Abstract: DHX15, a DEAH box containing RNA helicase, is a splicing factor required for the last step of splicing. Recent studies identified a recurrent mutational hotspot, R222G, in DHX15 in ~ 6% of acute myeloid leukemia (AML)… read more here.
Keywords: dhx15; tp53 mdm2; splicing factor; expression ... See more keywords
Targeting the TP53/MDM2 axis enhances radiation sensitivity in atypical teratoid rhabdoid tumors
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Oncology"
DOI: 10.3892/ijo.2022.5322
Abstract: Atypical teratoid rhabdoid tumor (ATRT) is a highly aggressive pediatric brain tumor. Despite radiation, aggressive chemotherapy and autologous stem cell rescue, children usually have a poor survival time. In the present study, the role of… read more here.
Keywords: tp53 mdm2; mdm2; inhibition; tp53 ... See more keywords
Association between polymorphisms in TP53 and MDM2 genes and susceptibility to prostate cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology letters"
DOI: 10.3892/ol.2017.5739
Abstract: Tumor protein 53 (TP53), a tumor suppressor gene, is a vital cellular cancer suppressor in multicellular organisms. Murine double minute-2 (MDM2) is an oncoprotein that inhibits TP53 activity. A number of studies have examined the… read more here.
Keywords: tp53 mdm2; prostate cancer; susceptibility prostate; cancer ... See more keywords