ROS modifiers and NOX4 affect the expression of the survivin‐associated radio‐adaptive response
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.547
Abstract: Abstract The survivin‐associated radio‐adaptive response can be induced following exposure to ionizing radiation in the dose range from 5 to 100 mGy, and its magnitude of expression is dependent upon the TP53 mutational status of… read more here.
Keywords: response; survivin; adaptive response; tp53 mut ... See more keywords
Molecular characteristics and clinical implications of TP53 mutations in therapy-related myelodysplastic syndromes
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DOI: 10.1038/s41408-025-01276-y
Abstract: Dear editor , TP53 mutations ( TP53 mut ) are observed in approximately 10% of patients with myelodysplastic syndromes (MDS) and associated with a high risk of acute myeloid leukemia (AML) transformation, poor response to… read more here.
Keywords: tp53 mutations; tp53 mut; myelodysplastic syndromes; molecular characteristics ... See more keywords
ADAR1 Is a Vulnerability in TP53-Mutant Acute Myeloid Leukemia
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DOI: 10.1182/blood-2024-208594
Abstract: Among the various subtypes of AML, each defined by distinct oncogenic mutations, those harboring mutations in the tumor suppressor gene TP53 are the most aggressive, presenting a significant clinical challenge. Notably, while TP53 mutations are… read more here.
Keywords: loss; tp53 mut; cell lines; tp53 ... See more keywords
Distinguishing tumor vs. clonal hematopoiesis (CH)–derived TP53 and BRCA1/2 alterations in ovarian cancer liquid biopsies with a predictive algorithm to inform clinical decision-making.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.5592
Abstract: 5592 Background: CH results from mutations in hematopoietic stem cells and can occur in clinically relevant genes that are detected in liquid biopsy (LBx) of solid tumor patients. TP53 and less frequently BRCA1/2 can be… read more here.
Keywords: mut; tumor; brca1 mut; tp53 mut ... See more keywords
Impact of TP53 mutation status on cancer-specific survival after first-line treatment in lymphoplasmacytic lymphoma.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.e19573
Abstract: e19573 Background: Lymphoplasmacytic lymphoma (LPL) is an indolent B-cell neoplasm encompassing Waldenström macroglobulinemia (WM) and non-IgM LPL. Testing for MYD88 and CXCR4 mutations is part of routine clinical workup of LPL; these mutations have relevance… read more here.
Keywords: treatment; tp53 mut; first line; mutation ... See more keywords
Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073815
Abstract: Children with high-risk SHH/TP53-mut and Group 3 medulloblastoma (MB) have a 5-year overall survival of only 40%. Innovative approaches to enhance survival while preventing adverse effects are urgently needed. We investigated an innovative therapy approach… read more here.
Keywords: tp53 mut; therapy; shh tp53; bearing mice ... See more keywords