TP53 mutation and survival in aggressive B cell lymphoma
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30838
Abstract: TP53 is mutated in 20–25% of aggressive B‐cell lymphoma (B‐NHL). To date, no studies have addressed the impact of TP53 mutations in prospective clinical trial cohorts. To evaluate the impact of TP53 mutation to current… read more here.
Keywords: tp53 mutation; aggressive cell; tp53; tp53 mutations ... See more keywords
Mutation of the TP53 gene in acute lymphoblastic leukemia does not affect survival outcomes after haploidentical hematopoietic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34323
Abstract: Previous studies have demonstrated that TP53 mutation is correlated with insufficient therapy response and unfavorable prognosis in acute lymphoblastic leukemia (ALL). Few studies have investigated the impact of TP53 mutation in ALL patients after haploidentical… read more here.
Keywords: cell; year; survival; acute lymphoblastic ... See more keywords
The Long-To-Short-Axis Ratio and Multifocality are Associated With TP53 Mutation Status in Surgically Resected Hepatocellular Carcinomas.
Sign Up to like & getrecommendations! Published in 2018 at "Academic radiology"
DOI: 10.1016/j.acra.2018.04.021
Abstract: RATIONALE AND OBJECTIVES In hepatocellular carcinoma (HCC), the tumor protein 53 (TP53) gene is frequently mutated and the mutations have been associated with poor prognosis. We aim to retrospectively identify the relationship between TP53 mutation… read more here.
Keywords: tp53 mutation; mutation status; ratio; multifocality ... See more keywords
Constitutional mosaicism of a de novo TP53 mutation in a patient with bilateral choroid plexus carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2017.07.001
Abstract: Choroid plexus tumors (CPT) constitute 2%-5% of all pediatric brain tumors and include high grade choroid plexus carcinoma (CPC). About 40% of CPC patients harbor germline TP53 mutations, associated with diminished survival rates. However, the… read more here.
Keywords: choroid plexus; tp53 mutation; mosaicism; novo tp53 ... See more keywords
The role of distinct co-mutation patterns with TP53 mutation in immunotherapy for NSCLC
Sign Up to like & getrecommendations! Published in 2020 at "Genes and Diseases"
DOI: 10.1016/j.gendis.2020.04.001
Abstract: Abstract TP53 mutations was reported to be correlated to the efficacy of program death-1 (PD-1) and program death ligand-1 (PD-L1). The role of co-mutations of TP53 with other recurrently mutated genes in outcome of anti-PD-(L)1… read more here.
Keywords: mutation 240; tp53 mutation; nsclc patients; longer pfs ... See more keywords
Frequent occurrence of CD19-negative relapse after CD19 CAR T and consolidation therapy in 14 TP53-mutated r/r B-ALL children
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-0831-z
Abstract: Despite high remission rates after CD19 CAR T-cell therapy in patients with refractory or relapsed B acute lymphoblastic leukemia (r/r B-ALL), relapses were commonly observed [1–4]. To improve long-term disease-free survival (DFS), our and other… read more here.
Keywords: cd19; tp53 mutation; therapy; car ... See more keywords
Recommendation for TP53 mutation testing in newly diagnosed mantle cell lymphoma: a statement from working groups sponsored by the Victorian Comprehensive Cancer Centre
Sign Up to like & getrecommendations! Published in 2022 at "Internal Medicine Journal"
DOI: 10.1111/imj.15851
Abstract: The Victorian Comprehensive Cancer Centre consortium sponsored representative working groups to review the role of TP53 mutation testing in the management of newly diagnosed mantle cell lymphoma (MCL). For many patients with this diagnosis, MCL… read more here.
Keywords: newly diagnosed; tp53; tp53 mutation; cell lymphoma ... See more keywords
Abstract 3613: Development of TP53 targeted treatment strategy in esophageal squamous cell carcinoma based on clinical information, TP53 mutation status and p53 RNA expression level
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-3613
Abstract: [Background] Recently, cancer genomic medicine has been promoted, and he demand for prognostic information and development of new treatments are expected. Especially, gene panel tests using NGS has been covered by insurance on June 1,… read more here.
Keywords: cell; tp53 mutation; mutation; mutation status ... See more keywords
Desmoid Fibromatosis With TP53 Mutation and Striking Nuclear Pleomorphism.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of surgical pathology"
DOI: 10.1177/10668969231160255
Abstract: Desmoid fibromatosis is a myofibroblastic neoplasm of intermediate biologic potential, which has a strong predilection for local recurrence but does not metastasize. Arranged in long, sweeping fascicles with infiltrative borders, desmoid fibromatosis typically consists of… read more here.
Keywords: striking nuclear; pleomorphism; fibromatosis; desmoid fibromatosis ... See more keywords
TP53 mutation defines a unique subgroup within complex karyotype de novo and therapy-related MDS/AML.
Sign Up to like & getrecommendations! Published in 2022 at "Blood advances"
DOI: 10.1182/bloodadvances.2021006239
Abstract: A subset of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) show complex karyotype (CK), and these cases include a relatively high proportion of cases of therapy-related myeloid neoplasms and TP53 mutations. We aimed to… read more here.
Keywords: therapy related; mutation; tp53 mutation; aml ... See more keywords
A special prognostic indicator: tumor mutation burden combined with immune infiltrates in lung adenocarcinoma with TP53 mutation
Sign Up to like & getrecommendations! Published in 2021 at "Translational Cancer Research"
DOI: 10.21037/tcr-21-565
Abstract: Background TP53 mutation (TP53mut) is significantly associated with immunotherapy response in lung adenocarcinoma (LUAD), but not an ideal independent prognostic predictor for it. Here, we investigated a novel potential biomarker and constructed a model for… read more here.
Keywords: tp53 mutation; tp53mut patients; mutation; tp53mut ... See more keywords