Stepwise crosstalk between aberrant Nf1, Tp53 and Rb signalling pathways induces gliomagenesis in zebrafish
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DOI: 10.1093/brain/awaa404
Abstract: Abstract The molecular pathogenesis of glioblastoma indicates that RTK/Ras/PI3K, RB and TP53 pathways are critical for human gliomagenesis. Here, several transgenic zebrafish lines with single or multiple deletions of nf1, tp53 and rb1 in astrocytes,… read more here.
Keywords: nf1 tp53; gliomagenesis zebrafish; stepwise; tp53 rb1 ... See more keywords
Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer
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DOI: 10.1186/s12916-022-02298-0
Abstract: Both changes in circulating lipids represented by a validated poor prognostic 3-lipid signature (3LS) and somatic tumour genetic aberrations are individually associated with worse clinical outcomes in men with metastatic castration-resistant prostate cancer (mCRPC). A… read more here.
Keywords: tp53 rb1; cancer; clinical outcomes; genetic aberrations ... See more keywords