Abstract 3179: Spindle assembly checkpoint as a therapeutic target for TP53-mutated myeloid neoplasms
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DOI: 10.1158/1538-7445.am2024-3179
Abstract: Introduction TP53-mutated (TP53mut) myeloid neoplasms (MN) are a distinct entity of myeloid neoplasms with no effective therapies and poor survival (Grob et al, Blood 2022). The TP53-deficient state facilitates the downstream dysfunction of the spindle… read more here.
Keywords: tp53 mutated; tp53mut; cell; myeloid neoplasms ... See more keywords
A special prognostic indicator: tumor mutation burden combined with immune infiltrates in lung adenocarcinoma with TP53 mutation
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DOI: 10.21037/tcr-21-565
Abstract: Background TP53 mutation (TP53mut) is significantly associated with immunotherapy response in lung adenocarcinoma (LUAD), but not an ideal independent prognostic predictor for it. Here, we investigated a novel potential biomarker and constructed a model for… read more here.
Keywords: tp53 mutation; tp53mut patients; mutation; tp53mut ... See more keywords
Prospective study of the efficacy and utility of TP53 mutations in circulating tumor DNA as a non-invasive biomarker of treatment response monitoring in patients with high-grade serous ovarian carcinoma
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DOI: 10.3802/jgo.2019.30.e32
Abstract: Objective Somatic TP53 mutation (TP53mut) is a characteristic finding in high-grade serous ovarian cancer (HGSOC). The aim of this study was to assess the clinical efficacy and utility of TP53mut circulating tumor DNA (ctDNA) monitoring… read more here.
Keywords: tumor; dna; utility; treatment ... See more keywords