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   Articles with "tp63" as a keyword



The TDP‐43/TP63 Positive Feedback Circuit Promotes Esophageal Squamous Cell Carcinoma Progression

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202402913

Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies with a 5‐year survival rate of only 15% in patients with advanced diseases. Tumor protein 63 (TP63), a master transcription factor (TF) in… read more here.

Keywords: esophageal squamous; tp63; cell carcinoma; squamous cell ... See more keywords

PBX-WNT-P63-IRF6 pathway in nonsyndromic cleft lip and palate.

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recommendations! Published in 2019 at "Birth defects research"

DOI: 10.1002/bdr2.1630

Abstract: Nonsyndromic cleft lip and palate (NSCLP) is one of the most common craniofacial anomalies in humans, affecting more than 135,000 newborns worldwide. NSCLP has a multifactorial etiology with more than 50 genes postulated to play… read more here.

Keywords: hispanic families; tp63; etiology; nonsyndromic cleft ... See more keywords

Dominant TP63 missense variants lead to constitutive activation and premature ovarian insufficiency

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recommendations! Published in 2022 at "Human Mutation"

DOI: 10.1002/humu.24432

Abstract: Premature ovarian insufficiency (POI) is a leading form of female infertility, characterised by menstrual disturbance and elevated follicle‐stimulating hormone before age 40. It is highly heterogeneous with variants in over 80 genes potentially causative, but… read more here.

Keywords: poi; p63; tp63; missense variants ... See more keywords

A Novel TP63 Missense Mutation in the Sumoylation Motif Causes Isolated Split‐Hand/Foot Malformation 4: A Pedigree Report and Literature Review

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recommendations! Published in 2025 at "Molecular Genetics & Genomic Medicine"

DOI: 10.1002/mgg3.70140

Abstract: Heterozygous TP63 mutations cause a spectrum of disorders including split‐hand/foot malformation 4 (SHFM4) and ectrodactyly‐ectodermal dysplasia‐cleft lip/palate syndrome 3 (EEC3). While some SHFM4 mutations concurrently induce EEC3‐like phenotypes (designated SHFM4/EEC3 mutations), their prevalence and distribution—particularly… read more here.

Keywords: split hand; tp63; foot malformation; hand foot ... See more keywords

Computational modeling of TP63-TP53 interaction and rational design of inhibitors: Implications for therapeutics.

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recommendations! Published in 2022 at "Molecular cancer therapeutics"

DOI: 10.1158/1535-7163.mct-22-0008

Abstract: Tumor protein p63 (TP63) is a member of the TP53 protein family that are important for development and in tumor suppression. Unlike TP53, TP63 is rarely mutated in cancer, but instead different TP63 isoforms regulate… read more here.

Keywords: interaction; tp63; tp53; tp63 tp53cm ... See more keywords
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The Impact of Upfront Autologous Transplant on the Survival of Adult Patients with ALCL and PTCL-NOS According to Their ALK, DUSP22 and TP63 Gene Rearrangement Status - a Joined Nordic Lymphoma Group and Mayo Clinic Analysis

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recommendations! Published in 2017 at "Blood"

DOI: 10.1182/blood.v130.suppl_1.822.822

Abstract: Introduction: Recent results from two independent patient series have shown that chromosomal rearrangements of DUSP22 (DUSP22r+) and TP63 (TP63r+) can predict outcome in ALK-negative anaplastic large cell lymphoma (ALK-ALCL) and peripheral T-cell lymphoma, not otherwise… read more here.

Keywords: alk; tp63; alk alcl; tp63r ... See more keywords

TP63 transcriptionally regulates SLC7A5 to suppress ferroptosis in head and neck squamous cell carcinoma

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recommendations! Published in 2024 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2024.1445472

Abstract: Background Most head and neck squamous cell carcinoma (HNSCC) patients are diagnosed at an advanced local stage. While immunotherapy has improved survival rates, only a minority of patients respond durably to targeted immunotherapies, posing substantial… read more here.

Keywords: tp63; head neck; slc7a5; ferroptosis ... See more keywords
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TGF-β1 Promotes Autophagy and Inhibits Apoptosis in Breast Cancer by Targeting TP63

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recommendations! Published in 2022 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2022.865067

Abstract: Background Breast cancer (BC) is a prevalent female cancer, which has high morbidity and mortality. However, the pathogenesis of BC has not been fully elucidated. Studies have shown that TGF-β1 plays an important role in… read more here.

Keywords: breast cancer; apoptosis breast; cancer; tp63 ... See more keywords

A Rare Case of TP63-Associated Lymphopenia Revealed by Newborn Screening Using TREC

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recommendations! Published in 2024 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms251910844

Abstract: The expanded newborn screening (NBS) program in the Russian Federation was initiated in 2023, among which severe combined immunodeficiency (SCID) is screened using TREC/KREC assays. Here, we report a rare case of a TP63-associated disease… read more here.

Keywords: newborn screening; tp63 associated; tp63; using trec ... See more keywords