A Fibrinogen‐Mimicking, Activated‐Platelet‐Sensitive Nanocoacervate Enhances Thrombus Targeting and Penetration of Tissue Plasminogen Activator for Effective Thrombolytic Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201265
Abstract: The development of a fibrinolytic system with long circulation time, high thrombus targeting, efficient thrombus penetration, effective thrombolysis, and minimal hemorrhagic risk remains a major challenge. Herein, inspired by fibrinogen binding to activated platelets in… read more here.
Keywords: rgd chi; penetration; tpa; chi tpa ... See more keywords
tPA variant tPA‐A296–299 Prevents impairment of cerebral autoregulation and necrosis of hippocampal neurons after stroke by inhibiting upregulation of ET‐1
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24112
Abstract: Tissue‐type plasminogen activator (tPA) is neurotoxic and exacerbates uncoupling of cerebral blood flow (CBF) and metabolism after stroke, yet it remains the sole FDA‐approved drug for treatment of ischemic stroke. Upregulation of c‐Jun‐terminal kinase (JNK)… read more here.
Keywords: autoregulation; a296 299; autoregulation necrosis; tpa ... See more keywords
Optimization of Microwave-Assisted Preparation of TPA from Waste PET Using Response Surface Methodology
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Polymers and the Environment"
DOI: 10.1007/s10924-017-0952-2
Abstract: Terephthalic acid (TPA) was prepared from waste polyethylene terephthalate by microwave-assisted depolymerization with TOMAB as catalyst, the structure and properties of TPA were elucidated by using physico-chemical and spectroscopic methods. Single-factors experiments demonstrated that the… read more here.
Keywords: methodology; tpa; response surface; waste ... See more keywords
Diabetes Worsens Functional Outcomes in Young Female Rats: Comparison of Stroke Models, Tissue Plasminogen Activator Effects, and Sexes
Sign Up to like & getrecommendations! Published in 2017 at "Translational Stroke Research"
DOI: 10.1007/s12975-017-0525-7
Abstract: Diabetes worsens stroke outcome and increases the risk of hemorrhagic transformation (HT) after ischemic stroke, especially with tissue plasminogen activator (tPA) treatment. The widespread use of tPA is still limited by the fear of hemorrhagic… read more here.
Keywords: tpa; diabetes worsens; plasminogen activator; tissue plasminogen ... See more keywords
A literature-based cost analysis of tissue plasminogen activator for prevention of biliary stricture in donation after circulatory death liver transplantation.
Sign Up to like & getrecommendations! Published in 2018 at "American journal of surgery"
DOI: 10.1016/j.amjsurg.2018.04.004
Abstract: INTRODUCTION This study sought to approximate the cost-effectiveness of tPA utilization for prevention of biliary strictures (PTBS) in donation after circulatory death liver transplantation (DCD-LT). METHODS Previously-reported PTBS rates in DCD-LT with and without tPA… read more here.
Keywords: tpa; donation circulatory; prevention biliary; ptbs ... See more keywords
Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2017.10.024
Abstract: 12/15-Lipoxygenase (12/15-LOX) contributes to the brain damage after middle cerebral artery occlusion (MCAO) in the acute phase of stroke. The aim of this study was to investigate the effects of a 12/15-LOX inhibitor, LOXBlock-1(LB1), in… read more here.
Keywords: fecl3 induced; tpa; distal mcao; lb1 ... See more keywords
Prevalence of early neurological deterioration after I.V – thrombolysis in acute ischaemic stroke patients – A hospital-based cohort study
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2018.05.003
Abstract: OBJECTIVES Early Neurological Deterioration (END) occur in up to 25% of patients with ischaemic stroke receiving stroke-unit-care and in 11-13.8% of patients treated with iv-tissue-Plasmniogen-Activator (iv-tPA). The aim of the study was to establish and… read more here.
Keywords: neurological deterioration; tpa; cohort; stroke ... See more keywords
Electroactive and ambipolar electrochromic polyimides from arylene diimides with triphenylamine N-substituents
Sign Up to like & getrecommendations! Published in 2017 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2017.05.031
Abstract: Abstract Three bis(triphenylamine) diimides, TPA-PMDI, TPA-NTDI and TPA-PTDI, were synthesized from condensation of 4-aminotriphenylamine with pyromellitic dianhydride (PMDA), 1,4,5,8-naphthalenetetracarboxylic dianhydride (NTDA) and 3,4,9,10-perylenetetracarboxylic dianhydride (PTDA), respectively. Redox-active poly(arylamine-imide) films coded with TPA-PMPI, TPA-NTPI, and TPA-PTPI… read more here.
Keywords: electrochromic polyimides; tpa; arylene diimides; ambipolar electrochromic ... See more keywords
Real-time monitoring of lipid droplets growth via the fusion with fluorescent dye-labeled adiposomes
Sign Up to like & getrecommendations! Published in 2020 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2020.108653
Abstract: Abstract Investigating lipid droplets (LDs) behaviours is essential to deeply understand the physiology of LDs, such as their growths, movements, fusion/division, and autophagy. Among these behaviours, the growth of LDs is one of the most… read more here.
Keywords: tpa; lipid droplets; fluorescent dye; fusion ... See more keywords
Single molecular-based nanoparticles with aggregation-induced emission characteristics for fluorescence imaging and efficient cancer phototherapy
Sign Up to like & getrecommendations! Published in 2021 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2020.109130
Abstract: Abstract Organic nanomaterials have garnered extensive interest in PDT/PTT due to their excellent photo-stability, efficient photothermal and reactive oxygen species generation ability. However, most organic nanomaterials emit very weak in the aggregated state because of… read more here.
Keywords: tpa nps; bodipy tpa; tpa; aggregation induced ... See more keywords
Is the photovoltaic poverty alleviation project the best way for the poor to escape poverty? ——A DEA and GRA analysis of different projects in rural China
Sign Up to like & getrecommendations! Published in 2020 at "Energy Policy"
DOI: 10.1016/j.enpol.2019.111105
Abstract: Abstract The solar photovoltaic poverty alleviation project (PPAP) is an important innovation in China's targeted poverty alleviation (TPA) mission. Through investment in the renewable energy industry and an emphasis on poverty alleviation in rural areas,… read more here.
Keywords: poverty alleviation; poverty; tpa; analysis ... See more keywords