Genetic variations in the p11/tPA/BDNF pathway are associated with post stroke depression.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2017.09.055
Abstract: BACKGROUND The effects of BDNF on post stroke depression (PSD) may be influenced by genetic variations in intracellular signal transduction pathways, such as the p11/tPA/BDNF pathway. In this study, we aimed to determine the association… read more here.
Keywords: bdnf pathway; tpa bdnf; p11 tpa; genetic variations ... See more keywords
The serum protein levels of the tPA–BDNF pathway are implicated in depression and antidepressant treatment
Sign Up to like & getrecommendations! Published in 2017 at "Translational Psychiatry"
DOI: 10.1038/tp.2017.43
Abstract: Evidence demonstrates that brain-derived neurotrophic factor (BDNF) has a pivotal role in the pathogenesis of major depressive disorder (MDD). Precursor-BDNF (proBDNF) and mature BDNF (mBDNF) have opposing biological effects in neuroplasticity, and the tissue-type plasminogen… read more here.
Keywords: bdnf pathway; treatment; probdnf; tpa bdnf ... See more keywords