Genetic Inactivation of Two-Pore Channel 1 Impairs Spatial Learning and Memory
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DOI: 10.1007/s10519-020-10011-1
Abstract: Two-pore channels (TPCs) constitute a small family of cation channels that are localized in membranes of endosomal and lysosomal compartments. Although their roles for vesicular fusion and endolysosomal trafficking have been investigated, our knowledge on… read more here.
Keywords: tpc1; tpc1 mice; learning memory; genetic inactivation ... See more keywords
TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity
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DOI: 10.1073/pnas.1920122117
Abstract: Significance The worldwide prevalence of allergic and anaphylactic reactions has increased massively over recent decades. Mast cells and basophils are essential drivers of these diseases, releasing inflammatory mediators such as histamine. Here, we link the… read more here.
Keywords: tpc1; mast; release; mast cell ... See more keywords
NAADP‐induced intracellular calcium ion is mediated by the TPCs (two‐pore channels) in hypoxia‐induced pulmonary arterial hypertension
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DOI: 10.1111/jcmm.16783
Abstract: Pulmonary arterial hypertension (PAH) is a form of obstructive vascular disease. Chronic hypoxic exposure leads to excessive proliferation of pulmonary arterial smooth muscle cells and pulmonary arterial endothelial cells. This condition can potentially be aggravated… read more here.
Keywords: tpc1; arterial hypertension; naadp induced; pulmonary arterial ... See more keywords