Characterization of cereblon-dependent targeted protein degrader by visualizing the spatiotemporal ternary complex formation in cells
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DOI: 10.1038/s41598-020-59966-5
Abstract: Targeted protein degradation (TPD) through a proteasome-dependent pathway induced by heterofunctional small molecules is initiated by the formation of a ternary complex with recruited E3 ligases. This complex formation affects the degradation ability of TPD… read more here.
Keywords: ternary complex; complex formation; formation; tpd molecules ... See more keywords