Identification of T Peripheral Helper (Tph) Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1736-6_6
Abstract: T peripheral helper (Tph) cells represent a T cell population that stimulates B cell responses within peripheral tissues. Like T follicular helper (Tfh) cells, PD-1hi CXCR5- CD4+ Tph cells produce IL-21 and CXCL13, yet these… read more here.
Keywords: tph; peripheral helper; tph cells; tfh cells ... See more keywords
Expanded circulating peripheral helper T cells in primary biliary cholangitis: Tph cells in PBC.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.09.007
Abstract: BACKGROUND Peripheral helper T (TPH) cells, a recently defined subset of Th cells, promote B cell differentiation and antibody production in inflamed tissues. This study investigated whether circulating TPH cells are associated with primary biliary… read more here.
Keywords: tph; peripheral helper; tph cells; pbc ... See more keywords
Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells 2. IFN-α and IFN-λ1 cooperatively contribute to the expansion of Tph cells in systemic lupus erythematosus.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac032
Abstract: Interleukin (IL)-21-producing T peripheral helper (Tph) cells are thought to contribute to extra-follicular B cell activation and play a pathogenic role in autoimmune diseases. In this study, we investigated relationship between Tph cells and interferons… read more here.
Keywords: ifn ifn; tph; role; tph cells ... See more keywords
Distinct features between HLA-DR+ and HLA-DR- PD-1hi CXCR5- T peripheral helper cells in seropositive rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2020 at "Rheumatology"
DOI: 10.1093/rheumatology/keaa417
Abstract: OBJECTIVES PD-1hi CXCR5- T peripheral helper (Tph) cells are newly identified pathogenic CD4 helper T cells in RA. We evaluated the usefulness of Tph cell subsets as biomarkers of RA. METHODS RA patients who visited… read more here.
Keywords: tph; hla tph; cell subsets; tph cells ... See more keywords
Competitive Binding of Transcription Factors Underlies Flexibility of T Peripheral Helper Cells and T Follicular Helper Cells in SLE.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac112
Abstract: OBJECTIVE Peripheral helper T (Tph) cells interact with B cells and promote immune responses at sites of ectopic lymphoid structures (ELSs). To assess the characteristics of Tph cells, we investigated the phenotype of T helper… read more here.
Keywords: tph cells; peripheral helper; helper; helper cells ... See more keywords
PD-1+CXCR5-CD4+T cells are correlated with the severity of systemic lupus erythematosus.
Sign Up to like & getrecommendations! Published in 2019 at "Rheumatology"
DOI: 10.1093/rheumatology/kez228
Abstract: OBJECTIVES PD-1+CXCR5-CD4+T peripheral helper (Tph) cells, a recently identified T cell subset, are proven to promote B cell responses and antibody production in rheumatoid arthritis, but their role in the pathogenesis of SLE is unknown.… read more here.
Keywords: tph; cd4 cells; tph cells; cells correlated ... See more keywords
T peripheral helper cells in autoimmune diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Immunological reviews"
DOI: 10.1111/imr.13069
Abstract: Pathologic T cell-B cell interactions underlie many autoimmune diseases. The T cells that help B cells in autoimmune diseases vary in phenotype and include T cells that lack typical features of T follicular helper cells,… read more here.
Keywords: tph cells; helper cells; cell; autoimmune diseases ... See more keywords
Peripheral Helper T Cell Responses in Human Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.946786
Abstract: A series of rheumatoid arthritis (RA) studies established a PD-1hiCXCR5-CD4+ T-cell subset that was coined peripheral helper T (Tph) cells. CXCL13 production is a key feature of Tph cells and may contribute to the formation… read more here.
Keywords: human diseases; cell; peripheral helper; tph cells ... See more keywords
Tph Cells Expanded in Primary Sjögren’s Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.900349
Abstract: Objectives PD-1+CXCR5–CD4+T peripheral helper cells, named Tph cells, contribute to B-cell immune responses and the production of antibodies in systemic lupus erythematosus and rheumatoid arthritis. However, the role of Tph cells was unknown in the… read more here.
Keywords: primary gren; tph; gren syndrome; patients pss ... See more keywords