Tryptophan hydroxylase 2 as a therapeutic target for psychiatric disorders: focus on animal models
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2019.1634691
Abstract: ABSTRACT Introduction: Tryptophan hydroxylase 2 (TPH2) is the key, rate-limiting enzyme of serotonin (5-HT) synthesis in the brain. Some polymorphic variants of the human Tph2 gene are associated with psychiatric disorders. Area covered: This review… read more here.
Keywords: psychiatric disorders; tryptophan hydroxylase; tph2 activity; tph2 ... See more keywords
Brain perfusion bridges virtual-reality spatial behavior to TPH2 genotype for head acceleration events.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neurotrauma"
DOI: 10.1089/neu.2020.7016
Abstract: Neuroimaging demonstrates that athletes of collision sports can suffer significant changes to their brain in the absence of concussion, due to head acceleration event (HAE) exposure. In a sample of 24 male Division I collegiate… read more here.
Keywords: reaction time; virtual reality; head acceleration; tph2 ... See more keywords
Genetic depletion of 5-HT increases central apnea frequency and duration and dampens arousal but does not impact the circadian modulation of these variables.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00724.2018
Abstract: We examined the impact of serotonin (5-HT) on the frequency and duration of central apneic events and the frequency of accompanying arousals during nonrapid and rapid eye movement (NREM and REM, respectively) sleep across the… read more here.
Keywords: apneic events; frequency; frequency duration; duration ... See more keywords
Association of Fatigue With TPH2 Genetic Polymorphisms in Women With Irritable Bowel Syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Biological Research For Nursing"
DOI: 10.1177/1099800418806055
Abstract: Fatigue is the most common extraintestinal symptom in women with irritable bowel syndrome (IBS). Genetic polymorphisms of monoamines are associated with fatigue in many chronic diseases. In this pilot exploratory study, the primary aim was… read more here.
Keywords: women irritable; genetic polymorphisms; irritable bowel; fatigue ... See more keywords
In silico analysis of the tryptophan hydroxylase 2 (TPH2) protein variants related to psychiatric disorders
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0229730
Abstract: The tryptophan hydroxylase 2 (TPH2) enzyme catalyzes the first step of serotonin biosynthesis. Serotonin is known for its role in several homeostatic systems related to sleep, mood, and food intake. As the reaction catalyzed by… read more here.
Keywords: protein; analysis; psychiatric disorders; tryptophan hydroxylase ... See more keywords
TPH2 Deficiency Influences Neuroplastic Mechanisms and Alters the Response to an Acute Stress in a Sex Specific Manner
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00389
Abstract: Dysregulations of the central serotoninergic system have been implicated in several psychopathologies, characterized by different susceptibility between males and females. We took advantage of tryptophan hydroxylase 2 (TPH2) deficient rats, lacking serotonin specifically in the… read more here.
Keywords: neuroplastic mechanisms; response; response acute; acute stress ... See more keywords
Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.907437
Abstract: Human tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in the synthesis of serotonin. Its dysfunction has been implicated in various psychiatric disorders such as depression, autism, and bipolar disorder. TPH2 is typically decreased in… read more here.
Keywords: human tryptophan; cryo structure; structure; tph2 ... See more keywords