A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency
Sign Up to like & getrecommendations! Published in 2021 at "SLAS Discovery"
DOI: 10.1177/24725552211018198
Abstract: Triose phosphate isomerase deficiency (TPI Df) is an untreatable, childhood-onset glycolytic enzymopathy. Patients typically present with frequent infections, anemia, and muscle weakness that quickly progresses with severe neuromusclar dysfunction requiring aided mobility and often respiratory… read more here.
Keywords: triose phosphate; phosphate isomerase; tpi; tpi treatments ... See more keywords