Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK‐ERK and NF‐κB pathways in a model of chronic myeloid leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12186
Abstract: The introduction of tyrosine kinase inhibitors (TKI) has transformed chronic myeloid leukemia (CML) into a chronic disease with long‐term survival exceeding 85%. However, resistance of CML stem cells to TKI may contribute to the 50%… read more here.
Keywords: cml; myeloid leukemia; tpl2; resistance ... See more keywords
The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation
Sign Up to like & getrecommendations! Published in 2017 at "Science Signaling"
DOI: 10.1126/scisignal.aah4273
Abstract: A small-molecule inhibitor of the kinase TPL2 shows efficacy in rodent models of inflammation. Targeting inflammatory neutrophils Neutrophils and monocytes are innate immune cells that establish an inflammatory response to infection. Because of their numbers,… read more here.
Keywords: kinase; inflammation; p38; tpl2 ... See more keywords
Influenza-induced Tpl2 expression within alveolar epithelial cells is dispensable for host viral control and anti-viral immunity
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DOI: 10.1371/journal.pone.0262832
Abstract: Tumor progression locus 2 (Tpl2) is a serine/threonine kinase that regulates the expression of inflammatory mediators in response to Toll-like receptors (TLR) and cytokine receptors. Global ablation of Tpl2 leads to severe disease in response… read more here.
Keywords: airway epithelial; influenza; expression; lung epithelial ... See more keywords
Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes
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DOI: 10.1371/journal.pone.0266017
Abstract: Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer in the United States, affecting one million people per year. Patients with aggressive disease have limited treatment options and high mortality,… read more here.
Keywords: egfr; tpl2; inhibition; resistance egfr ... See more keywords