Muscle magnetic resonance imaging involvement patterns in nemaline myopathies.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of clinical and translational neurology"
DOI: 10.1002/acn3.51816
Abstract: OBJECTIVE Characterise the diagnostic and prognostic value of muscle MRI patterns as biomarkers in a genetically heterogeneous nemaline myopathy (NM) patient cohort. METHODS Modified Mercuri scoring of lower limb MRI in genetically characterised NM patients… read more here.
Keywords: tpm3; neb acta1; involvement; adductor ... See more keywords
Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47592-9
Abstract: Tropomyosins (Tpm) determine the functional capacity of actin filaments in an isoform-specific manner. The primary isoform in cancer cells is Tpm3.1 and compounds that target Tpm3.1 show promising results as anti-cancer agents both in vivo… read more here.
Keywords: coil overlap; compound atm; tpm3; cancer ... See more keywords
MiR-107 inhibits the malignant biological behavior of esophageal squamous cell carcinoma by targeting TPM3
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastrointestinal Oncology"
DOI: 10.21037/jgo-22-575
Abstract: Background Esophageal squamous cell carcinoma (ESCC) is a highly lethal and aggressive tumor. Our previous study revealed that tropomyosin 3 (TPM3) is up-regulated in the late stage of ESCC and promotes epithelial-mesenchymal transition (EMT) via… read more here.
Keywords: tpm3; mir 107; squamous cell; expression ... See more keywords
[Effects of tropomyosin 3 on pyroptosis of cardiomyocytes and fibroblast activation induced by hypoxia/reoxygenation in rats].
Sign Up to like & getrecommendations! Published in 2023 at "Zhonghua wei zhong bing ji jiu yi xue"
DOI: 10.3760/cma.j.cn121430-20221130-01045
Abstract: OBJECTIVE To explore the role of tropomyosin 3 (TPM3) in hypoxia/reoxygenation (H/R)-induced cardiomyocyte pyroptosis and fibroblast activation. METHODS Rat cardiomyocytes (H9c2 cells) were treated with H/R method to simulate myocardial ischemia/reperfusion (I/R) injury, and cell… read more here.
Keywords: tpm3; pyroptosis; collagen; fibroblast activation ... See more keywords