Structure and function of the TPR-domain immunophilins FKBP51 and FKBP52 in normal physiology and disease.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30406
Abstract: Coordinated cochaperone interactions with Hsp90 and associated client proteins are crucial for a multitude of signaling pathways in normal physiology, as well as in disease settings. Research on the molecular mechanisms regulated by the Hsp90… read more here.
Keywords: fkbp51 fkbp52; disease; domain immunophilins; physiology ... See more keywords
The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010750
Abstract: The synthesis of exopolysaccharides as biofilm matrix components by pathogens is a crucial factor for chronic infections and antibiotic resistance. Many periplasmic proteins involved in polymer processing and secretion in Gram-negative synthase dependent exopolysaccharide biosynthetic… read more here.
Keywords: polymer processing; tpr; tpr domain;
Crystal Structural Analysis of Oryza sativa SGT1-TPR Domain
Sign Up to like & getrecommendations! Published in 2025 at "Crystals"
DOI: 10.3390/cryst15060543
Abstract: SGT1 (the suppressor of the G2 allele of Skp1) functions as an adaptor protein that positively regulates plant defense and developmental processes. It comprises three functional domains: the tetratricopeptide repeat (TPR) domain, Chord SGT1 motif… read more here.
Keywords: oryza sativa; analysis; sgt1; tpr domain ... See more keywords