Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22596-0
Abstract: To adapt to fluctuating protein folding loads in the endoplasmic reticulum (ER), the Hsp70 chaperone BiP is reversibly modified with adenosine monophosphate (AMP) by the ER-resident Fic-enzyme FICD/HYPE. The structural basis for BiP binding and… read more here.
Keywords: tpr motifs; chaperone bip; motifs ficd; ampylation ... See more keywords
Emerging Functions of Human IFIT Proteins in Cancer
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DOI: 10.3389/fmolb.2019.00148
Abstract: Interferon-induced protein with tetratricopeptide repeats (IFIT) genes are prominent interferon-stimulated genes (ISGs). The human IFIT gene family consists of four genes named IFIT1, IFIT2, IFIT3, and IFIT5. The expression of IFIT genes is very low… read more here.
Keywords: tpr motifs; ifit proteins; ifit genes; human ifit ... See more keywords