TPX2 promotes ovarian tumorigenesis by interacting with Lamin A/C and affecting its stability
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5683
Abstract: Ovarian cancer (OC) is one of the fatal gynecologic malignancies. However, there are no effective prognostic or therapeutic indicators for OC. Herein, we aim to reveal the potential function of targeting protein for Xklp2 (TPX2)… read more here.
Keywords: ovarian tumorigenesis; tumorigenesis interacting; promotes ovarian; tpx2 promotes ... See more keywords
The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts.
Sign Up to like & getrecommendations! Published in 2025 at "Cytoskeleton"
DOI: 10.1002/cm.22034
Abstract: A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types. Targeting… read more here.
Keywords: egg extracts; tpx2 regulates; tpx2; xenopus egg ... See more keywords
Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.164
Abstract: Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is a microtubule-associated protein required for mitosis and spindle assembly. Previous studies showed that TPX2 is overexpressed in various human cancers and promotes cancer progression. In this… read more here.
Keywords: pi3k akt; breast cancer; signaling pathway; tpx2 ... See more keywords
Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-019-14087-0
Abstract: Phase separation of substrates and effectors is proposed to enhance biological reaction rates and efficiency. Targeting protein for Xklp2 (TPX2) is an effector of branching microtubule nucleation in spindles and functions with the substrate tubulin… read more here.
Keywords: microtubule nucleation; phase separation; tpx2;
Circular RNA circ-LARP1B contributes to cutaneous squamous cell carcinoma progression by targeting microRNA-515-5p/TPX2 microtubule nucleation factor axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2019172
Abstract: ABSTRACT Circular RNAs (circRNAs) have shown pivotal regulatory roles in tumorigenesis and progression. Our purpose was to analyze the role of circRNA La ribonucleoprotein 1B (circ-LARP1B; hsa_circ_0070934) in cutaneous squamous cell carcinoma (CSCC) progression and… read more here.
Keywords: circ; circ larp1b; tpx2; mir 515 ... See more keywords
Regulation of Kif15 localization and motility by the C-terminus of TPX2 and microtubule dynamics
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e16-06-0476
Abstract: Temporal and spatial regulation of mitotic motor proteins is required for proper spindle assembly and function. A single microtubule-associated protein, TPX2, regulates both kinesin-5 and kinesin-12 family members to support bipolar spindle formation and maintenance. read more here.
Keywords: microtubule; regulation kif15; tpx2; kif15 localization ... See more keywords
TPX2 serves as a novel target for expanding the utility of PARPi in pancreatic cancer through conferring synthetic lethality
Sign Up to like & getrecommendations! Published in 2024 at "Gut"
DOI: 10.1136/gutjnl-2024-332782
Abstract: Background PARP inhibitors (PARPi) have been licensed for the maintenance therapy of patients with metastatic pancreatic cancer carrying pathogenic germline BRCA1/2 mutations. However, mutations in BRCA1/2 are notably rare in pancreatic cancer. Objective There is… read more here.
Keywords: pancreatic cancer; tpx2; utility parpi; synthetic lethality ... See more keywords
Target Protein for Xklp2 Functions as Coactivator of Androgen Receptor and Promotes the Proliferation of Prostate Carcinoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/6085948
Abstract: The activation of the androgen receptor (AR) pathway is crucial in the progression of human prostate cancer. Results of the present study indicated that the target protein xenopus kinesin-like protein (TPX2) enhanced the transcription activation… read more here.
Keywords: proliferation; prostate; androgen receptor; tpx2 ... See more keywords
Structural bioinformatics predicts that the Retinitis Pigmentosa-28 protein of unknown function FAM161A is a homologue of the microtubule nucleation factor Tpx2
Sign Up to like & getrecommendations! Published in 2020 at "F1000Research"
DOI: 10.12688/f1000research.25870.1
Abstract: Background: FAM161A is a microtubule-associated protein conserved widely across eukaryotes, which is mutated in the inherited blinding disease Retinitis Pigmentosa-28. FAM161A is also a centrosomal protein, being a core component of a complex that forms… read more here.
Keywords: protein; microtubule; fam161a; retinitis pigmentosa ... See more keywords
TPX2 silencing exerts anti-tumor effects on hepatocellular carcinoma by regulating the PI3K/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2019.4371
Abstract: Hepatocellular carcinoma (HCC) is one of the primary causes of cancer-associated deaths worldwide. Current treatment methods include surgical resection, chemotherapy and radiotherapy; however the curative rate remains low, thus novel treatments are required. The aim… read more here.
Keywords: protein; tpx2 silencing; signaling pathway; tpx2 ... See more keywords
TPX2 silencing mediated by joint action of microvesicles and ultrasonic radiation inhibits the migration and invasion of SKOV3 cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2018.8810
Abstract: Ovarian cancer, with its high morbidity, has one of the highest mortality rates among gynecological malignant tumors. Overexpression of targeting protein for Xklp2 (TPX2) has been identified in numerous malignant tumors. The present study sought… read more here.
Keywords: skov3; microvesicles ultrasonic; tpx2; ultrasonic radiation ... See more keywords